Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

Lin Wei; Jiuxiang Gao; Shumin Zhang; Sijin Wu; Zeping Xie; Guiying Ling; Yi Qun Kuang; Yongliang Yang; Haining Yu; Yipeng Wang

doi:10.1074/jbc.M115.642645

Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

Lin Wei, Jiuxiang Gao, Shumin Zhang, Sijin Wu, Zeping Xie, Guiying Ling, Yi Qun Kuang, Yongliang Yang, Haining Yu^*, Yipeng Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.

Original language	English
Pages (from-to)	16633-16652
Number of pages	20
Journal	Journal of Biological Chemistry
Volume	290
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M115.642645
Publication status	Published - 3 Jul 2015
Externally published	Yes

Access to Document

10.1074/jbc.M115.642645

Cite this

@article{f91dbfa78c234c26a1a4cccb17337fb1,

title = "Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism",

abstract = "Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.",

author = "Lin Wei and Jiuxiang Gao and Shumin Zhang and Sijin Wu and Zeping Xie and Guiying Ling and Kuang, {Yi Qun} and Yongliang Yang and Haining Yu and Yipeng Wang",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = jul,

day = "3",

doi = "10.1074/jbc.M115.642645",

language = "English",

volume = "290",

pages = "16633--16652",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

number = "27",

}

TY - JOUR

T1 - Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

AU - Wei, Lin

AU - Gao, Jiuxiang

AU - Zhang, Shumin

AU - Wu, Sijin

AU - Xie, Zeping

AU - Ling, Guiying

AU - Kuang, Yi Qun

AU - Yang, Yongliang

AU - Yu, Haining

AU - Wang, Yipeng

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.

AB - Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.

UR - http://www.scopus.com/inward/record.url?scp=84936816932&partnerID=8YFLogxK

U2 - 10.1074/jbc.M115.642645

DO - 10.1074/jbc.M115.642645

M3 - Article

C2 - 26013823

AN - SCOPUS:84936816932

SN - 0021-9258

VL - 290

SP - 16633

EP - 16652

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 27

ER -

Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

Abstract

Access to Document

Other files and links

Fingerprint

Cite this