TY - GEN
T1 - Hybridizing behavioral models
T2 - A possible solution to some problems in neurophenotyping research?
AU - Kalueff, Allan V.
AU - LaPorte, Justin L.
AU - Murphy, Dennis L.
AU - Sufka, Kenneth
PY - 2008/7/1
Y1 - 2008/7/1
N2 - The use of batteries of single-domain tests for neurophenotyping research is a common strategy to achieve higher data density and explore different behavioral domains. This approach, however, is accompanied by several methodological challenges, briefly discussed here. As an alternative, this paper advocates the wider use of extensive "hybrid" protocols that assess multiple domains in parallel, or logically/logistically combine experimental paradigms, in a way that disproportionately maximizes the number of tested phenotypes per experimental manipulation. Several examples of this approach are given in this paper, demonstrating the potential to reduce time, cost and subject requirements for the experiments. Offering behavioral analyses that are lacking in the standard single-domain tests, such "hybrid" models enable innovative modeling of neuropsychiatric disorders by more thorough and broader investigation of complex phenotypical characteristics.
AB - The use of batteries of single-domain tests for neurophenotyping research is a common strategy to achieve higher data density and explore different behavioral domains. This approach, however, is accompanied by several methodological challenges, briefly discussed here. As an alternative, this paper advocates the wider use of extensive "hybrid" protocols that assess multiple domains in parallel, or logically/logistically combine experimental paradigms, in a way that disproportionately maximizes the number of tested phenotypes per experimental manipulation. Several examples of this approach are given in this paper, demonstrating the potential to reduce time, cost and subject requirements for the experiments. Offering behavioral analyses that are lacking in the standard single-domain tests, such "hybrid" models enable innovative modeling of neuropsychiatric disorders by more thorough and broader investigation of complex phenotypical characteristics.
KW - Behavioral phenotyping
KW - Experimental models
KW - High-throughput testing
KW - Research strategies
KW - Single and multiple domains
UR - http://www.scopus.com/inward/record.url?scp=49849088506&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2007.12.010
DO - 10.1016/j.pnpbp.2007.12.010
M3 - Other contribution
C2 - 18222590
AN - SCOPUS:49849088506
VL - 32
T3 - Progress in Neuro-Psychopharmacology and Biological Psychiatry
ER -