Homebase behavior of zebrafish in novelty-based paradigms

Adam Stewart; Jonathan Cachat; Keith Wong; Siddharth Gaikwad; Thomas Gilder; John DiLeo; Katie Chang; Eli Utterback; Allan V. Kalueff

doi:10.1016/j.beproc.2010.07.009

Homebase behavior of zebrafish in novelty-based paradigms

Adam Stewart, Jonathan Cachat, Keith Wong, Siddharth Gaikwad, Thomas Gilder, John DiLeo, Katie Chang, Eli Utterback, Allan V. Kalueff^*

^*Corresponding author for this work

Tulane University

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

Zebrafish (Danio rerio) are emerging as a promising model species in neuroscience research. Many traditional rodent behavioral paradigms may be adapted for zebrafish testing. Exposing zebrafish to three different " open field" tanks for 30min, we showed that fish display robust homebase behavior, in which one area of the tank is chosen as a preferred point of reference during the test, which the fish frequently return to and spend a longer duration in. This phenotype strikingly resembles rodent homebase behavior, confirming that both species use homebases as " reference points" for their exploration. Our study introduces a simple method for zebrafish homebase phenotyping, and further supports the utility of these fish in neurobehavioral and cognitive research.

Original language	English
Pages (from-to)	198-203
Number of pages	6
Journal	Behavioural Processes
Volume	85
Issue number	2
DOIs	https://doi.org/10.1016/j.beproc.2010.07.009
Publication status	Published - Oct 2010
Externally published	Yes

Keywords

Exploration
Homebase behavior
Open field test
Zebrafish

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10.1016/j.beproc.2010.07.009

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Stewart, A., Cachat, J., Wong, K., Gaikwad, S., Gilder, T., DiLeo, J., Chang, K., Utterback, E., & Kalueff, A. V. (2010). Homebase behavior of zebrafish in novelty-based paradigms. Behavioural Processes, 85(2), 198-203. https://doi.org/10.1016/j.beproc.2010.07.009

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AU - Wong, Keith

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AU - DiLeo, John

AU - Chang, Katie

AU - Utterback, Eli

AU - Kalueff, Allan V.

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Homebase behavior of zebrafish in novelty-based paradigms

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Keywords

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