Galectins - Potential targets for cancer therapy

Syed Saif Hasan; Ghulam Md Ashraf; Naheed Banu

doi:10.1016/j.canlet.2006.11.030

Galectins - Potential targets for cancer therapy

Syed Saif Hasan, Ghulam Md Ashraf, Naheed Banu^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

62 Citations (Scopus)

Abstract

Galectins are a family of galactose binding lectins that have become the focus of attention of cancer biologists due to their numerous regulatory roles in normal cellular metabolism and also because of their altered levels in various cancers. They are reportedly similar to several prominent and established modulators of apoptosis. In this review, we present a brief outline of the advancements in the methodology used to detect and identify them and their therapeutic applications in cancer. Their possible interactions with other glycoconjugates are also discussed and a vision for their future use in diagnosis and therapeutics is provided.

Original language	English
Pages (from-to)	25-33
Number of pages	9
Journal	Cancer Letters
Volume	253
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2006.11.030
Publication status	Published - 8 Aug 2007
Externally published	Yes

Keywords

Cancer
Detection
Galectins
Glycoconjugates
Inhibition
Metastasis
Therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2006.11.030

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title = "Galectins - Potential targets for cancer therapy",

abstract = "Galectins are a family of galactose binding lectins that have become the focus of attention of cancer biologists due to their numerous regulatory roles in normal cellular metabolism and also because of their altered levels in various cancers. They are reportedly similar to several prominent and established modulators of apoptosis. In this review, we present a brief outline of the advancements in the methodology used to detect and identify them and their therapeutic applications in cancer. Their possible interactions with other glycoconjugates are also discussed and a vision for their future use in diagnosis and therapeutics is provided.",

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author = "Hasan, {Syed Saif} and Ashraf, {Ghulam Md} and Naheed Banu",

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language = "English",

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T1 - Galectins - Potential targets for cancer therapy

AU - Hasan, Syed Saif

AU - Ashraf, Ghulam Md

AU - Banu, Naheed

PY - 2007/8/8

Y1 - 2007/8/8

N2 - Galectins are a family of galactose binding lectins that have become the focus of attention of cancer biologists due to their numerous regulatory roles in normal cellular metabolism and also because of their altered levels in various cancers. They are reportedly similar to several prominent and established modulators of apoptosis. In this review, we present a brief outline of the advancements in the methodology used to detect and identify them and their therapeutic applications in cancer. Their possible interactions with other glycoconjugates are also discussed and a vision for their future use in diagnosis and therapeutics is provided.

AB - Galectins are a family of galactose binding lectins that have become the focus of attention of cancer biologists due to their numerous regulatory roles in normal cellular metabolism and also because of their altered levels in various cancers. They are reportedly similar to several prominent and established modulators of apoptosis. In this review, we present a brief outline of the advancements in the methodology used to detect and identify them and their therapeutic applications in cancer. Their possible interactions with other glycoconjugates are also discussed and a vision for their future use in diagnosis and therapeutics is provided.

KW - Cancer

KW - Detection

KW - Galectins

KW - Glycoconjugates

KW - Inhibition

KW - Metastasis

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=34249978481&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2006.11.030

DO - 10.1016/j.canlet.2006.11.030

M3 - Review article

C2 - 17207926

AN - SCOPUS:34249978481

SN - 0304-3835

VL - 253

SP - 25

EP - 33

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Galectins - Potential targets for cancer therapy

Abstract

Keywords

UN SDGs

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