Frontier view on nanotechnological strategies for neuro-therapy

Asim Azhar; Ghulam Md Ashraf; Qamar Zia; Shakeel A. Ansari; Asma Perveen; Abdul Hafeez; Mohd Saeed; Mohammad A. Kamal; Athanasios Alexiou; Magdah Ganash; Nagendra S. Yarla; Saleh S. Baeesa; Mohamed M. Alfiky; Osama S. Bajouh

doi:10.2174/1389200219666180305144143

Frontier view on nanotechnological strategies for neuro-therapy

Asim Azhar, Ghulam Md Ashraf^*, Qamar Zia, Shakeel A. Ansari, Asma Perveen, Abdul Hafeez, Mohd Saeed, Mohammad A. Kamal, Athanasios Alexiou, Magdah Ganash, Nagendra S. Yarla, Saleh S. Baeesa, Mohamed M. Alfiky, Osama S. Bajouh

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Background: Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain. Objective: Nanotechnology based approaches (NBA) favours transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The last five years have witnessed the successful applications of NBA to treat neurological disorders. It is expected that the development of novel NBA will result in important insights on the brain mechanisms, and eventually provide better medical care to patients suffering from neurological disorders. Conclusion: This review introduces the emerging work in this area and summarizes the successful NBA used in recent past for treating various neurological disorders ike Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, meningitis and glioblastoma.

Original language	English
Pages (from-to)	596-604
Number of pages	9
Journal	Current Drug Metabolism
Volume	19
Issue number	7
DOIs	https://doi.org/10.2174/1389200219666180305144143
Publication status	Published - 2018
Externally published	Yes

Keywords

Alzheimer’s disease
Blood brain barrier
Drug delivery
Nanotechnology
Nanotechnology based approaches
Neurological disorders

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10.2174/1389200219666180305144143

Cite this

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title = "Frontier view on nanotechnological strategies for neuro-therapy",

abstract = "Background: Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain. Objective: Nanotechnology based approaches (NBA) favours transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The last five years have witnessed the successful applications of NBA to treat neurological disorders. It is expected that the development of novel NBA will result in important insights on the brain mechanisms, and eventually provide better medical care to patients suffering from neurological disorders. Conclusion: This review introduces the emerging work in this area and summarizes the successful NBA used in recent past for treating various neurological disorders ike Alzheimer{\textquoteright}s disease, Parkinson{\textquoteright}s disease, amyotrophic lateral sclerosis, meningitis and glioblastoma.",

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author = "Asim Azhar and Ashraf, {Ghulam Md} and Qamar Zia and Ansari, {Shakeel A.} and Asma Perveen and Abdul Hafeez and Mohd Saeed and Kamal, {Mohammad A.} and Athanasios Alexiou and Magdah Ganash and Yarla, {Nagendra S.} and Baeesa, {Saleh S.} and Alfiky, {Mohamed M.} and Bajouh, {Osama S.}",

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year = "2018",

doi = "10.2174/1389200219666180305144143",

language = "English",

volume = "19",

pages = "596--604",

journal = "Current Drug Metabolism",

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AU - Azhar, Asim

AU - Ashraf, Ghulam Md

AU - Zia, Qamar

AU - Ansari, Shakeel A.

AU - Perveen, Asma

AU - Hafeez, Abdul

AU - Saeed, Mohd

AU - Kamal, Mohammad A.

AU - Alexiou, Athanasios

AU - Ganash, Magdah

AU - Yarla, Nagendra S.

AU - Baeesa, Saleh S.

AU - Alfiky, Mohamed M.

AU - Bajouh, Osama S.

PY - 2018

Y1 - 2018

N2 - Background: Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain. Objective: Nanotechnology based approaches (NBA) favours transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The last five years have witnessed the successful applications of NBA to treat neurological disorders. It is expected that the development of novel NBA will result in important insights on the brain mechanisms, and eventually provide better medical care to patients suffering from neurological disorders. Conclusion: This review introduces the emerging work in this area and summarizes the successful NBA used in recent past for treating various neurological disorders ike Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, meningitis and glioblastoma.

AB - Background: Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain. Objective: Nanotechnology based approaches (NBA) favours transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The last five years have witnessed the successful applications of NBA to treat neurological disorders. It is expected that the development of novel NBA will result in important insights on the brain mechanisms, and eventually provide better medical care to patients suffering from neurological disorders. Conclusion: This review introduces the emerging work in this area and summarizes the successful NBA used in recent past for treating various neurological disorders ike Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, meningitis and glioblastoma.

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KW - Blood brain barrier

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KW - Nanotechnology based approaches

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Frontier view on nanotechnological strategies for neuro-therapy

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Keywords

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