Exploration of Graphitic-C3N4 Quantum Dots for Microwave-Induced Photodynamic Therapy

Xiao Chu; Kang Li; Hongyu Guo; Huibin Zheng; Suzanne Shuda; Xiaolan Wang; Junying Zhang; Wei Chen; Yu Zhang

doi:10.1021/acsbiomaterials.7b00110

Exploration of Graphitic-C₃N₄ Quantum Dots for Microwave-Induced Photodynamic Therapy

Xiao Chu, Kang Li, Hongyu Guo, Huibin Zheng, Suzanne Shuda, Xiaolan Wang, Junying Zhang^*, Wei Chen, Yu Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Here, we report our new observations on graphitic-phase carbon nitride (g-C₃N₄) quantum dots (QDs) as agents for microwave induced photodynamic therapy (MIPDT). For the first time, we observed that singlet oxygen is produced in g-C₃N₄ QDs by microwave irradiation, which can be used for tumor destruction. The results of live/dead staining and flow cytometry show that g-C₃N₄ QDs based MIPDT can effectively kill cancer cells and promote tumor cell death. In addition, the cell viability and hemolysis tests in vitro indicate that g-C₃N₄ QDs have very low cell toxicity and possess excellent biocompatibility in the physiological environments. All these indicate that g-C₃N₄ QDs are promising for MIPDT, a new potential modality for cancer treatment.

Original language	English
Pages (from-to)	1836-1844
Number of pages	9
Journal	ACS Biomaterials Science and Engineering
Volume	3
Issue number	8
DOIs	https://doi.org/10.1021/acsbiomaterials.7b00110
Publication status	Published - 14 Aug 2017
Externally published	Yes

Keywords

graphitic-CN quantum dots
microwave
microwave induced photodynamic therapy (MIPDT)
singlet oxygen
tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/acsbiomaterials.7b00110

Cite this

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title = "Exploration of Graphitic-C3N4 Quantum Dots for Microwave-Induced Photodynamic Therapy",

abstract = "Here, we report our new observations on graphitic-phase carbon nitride (g-C3N4) quantum dots (QDs) as agents for microwave induced photodynamic therapy (MIPDT). For the first time, we observed that singlet oxygen is produced in g-C3N4 QDs by microwave irradiation, which can be used for tumor destruction. The results of live/dead staining and flow cytometry show that g-C3N4 QDs based MIPDT can effectively kill cancer cells and promote tumor cell death. In addition, the cell viability and hemolysis tests in vitro indicate that g-C3N4 QDs have very low cell toxicity and possess excellent biocompatibility in the physiological environments. All these indicate that g-C3N4 QDs are promising for MIPDT, a new potential modality for cancer treatment.",

keywords = "graphitic-CN quantum dots, microwave, microwave induced photodynamic therapy (MIPDT), singlet oxygen, tumor",

author = "Xiao Chu and Kang Li and Hongyu Guo and Huibin Zheng and Suzanne Shuda and Xiaolan Wang and Junying Zhang and Wei Chen and Yu Zhang",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

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T1 - Exploration of Graphitic-C3N4 Quantum Dots for Microwave-Induced Photodynamic Therapy

AU - Chu, Xiao

AU - Li, Kang

AU - Guo, Hongyu

AU - Zheng, Huibin

AU - Shuda, Suzanne

AU - Wang, Xiaolan

AU - Zhang, Junying

AU - Chen, Wei

AU - Zhang, Yu

PY - 2017/8/14

Y1 - 2017/8/14

N2 - Here, we report our new observations on graphitic-phase carbon nitride (g-C3N4) quantum dots (QDs) as agents for microwave induced photodynamic therapy (MIPDT). For the first time, we observed that singlet oxygen is produced in g-C3N4 QDs by microwave irradiation, which can be used for tumor destruction. The results of live/dead staining and flow cytometry show that g-C3N4 QDs based MIPDT can effectively kill cancer cells and promote tumor cell death. In addition, the cell viability and hemolysis tests in vitro indicate that g-C3N4 QDs have very low cell toxicity and possess excellent biocompatibility in the physiological environments. All these indicate that g-C3N4 QDs are promising for MIPDT, a new potential modality for cancer treatment.

AB - Here, we report our new observations on graphitic-phase carbon nitride (g-C3N4) quantum dots (QDs) as agents for microwave induced photodynamic therapy (MIPDT). For the first time, we observed that singlet oxygen is produced in g-C3N4 QDs by microwave irradiation, which can be used for tumor destruction. The results of live/dead staining and flow cytometry show that g-C3N4 QDs based MIPDT can effectively kill cancer cells and promote tumor cell death. In addition, the cell viability and hemolysis tests in vitro indicate that g-C3N4 QDs have very low cell toxicity and possess excellent biocompatibility in the physiological environments. All these indicate that g-C3N4 QDs are promising for MIPDT, a new potential modality for cancer treatment.

KW - graphitic-CN quantum dots

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