Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation

Liyi Huang; Lun Ma; Weijun Xuan; Xiumei Zhen; Han Zheng; Wei Chen; Michael R. Hamblin

doi:10.1166/jbn.2019.2829

Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation

Liyi Huang^*, Lun Ma, Weijun Xuan, Xiumei Zhen, Han Zheng, Wei Chen, Michael R. Hamblin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.

Original language	English
Pages (from-to)	2142-2148
Number of pages	7
Journal	Journal of Biomedical Nanotechnology
Volume	15
Issue number	10
DOIs	https://doi.org/10.1166/jbn.2019.2829
Publication status	Published - 2019
Externally published	Yes

Keywords

Antimicrobial photodynamic inactivation
Copper-cysteamine nanoparticles
Gram-negative bacteria
Gram-positive bacteria
Reactive oxygen species

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1166/jbn.2019.2829

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title = "Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation",

abstract = "Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.",

keywords = "Antimicrobial photodynamic inactivation, Copper-cysteamine nanoparticles, Gram-negative bacteria, Gram-positive bacteria, Reactive oxygen species",

author = "Liyi Huang and Lun Ma and Weijun Xuan and Xiumei Zhen and Han Zheng and Wei Chen and Hamblin, {Michael R.}",

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year = "2019",

doi = "10.1166/jbn.2019.2829",

language = "English",

volume = "15",

pages = "2142--2148",

journal = "Journal of Biomedical Nanotechnology",

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TY - JOUR

T1 - Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation

AU - Huang, Liyi

AU - Ma, Lun

AU - Xuan, Weijun

AU - Zhen, Xiumei

AU - Zheng, Han

AU - Chen, Wei

AU - Hamblin, Michael R.

PY - 2019

Y1 - 2019

N2 - Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.

AB - Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.

KW - Antimicrobial photodynamic inactivation

KW - Copper-cysteamine nanoparticles

KW - Gram-negative bacteria

KW - Gram-positive bacteria

KW - Reactive oxygen species

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U2 - 10.1166/jbn.2019.2829

DO - 10.1166/jbn.2019.2829

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SN - 1550-7033

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IS - 10

ER -

Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation

Abstract

Keywords

UN SDGs

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