Abstract
Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.
| Original language | English |
|---|---|
| Pages (from-to) | 2142-2148 |
| Number of pages | 7 |
| Journal | Journal of Biomedical Nanotechnology |
| Volume | 15 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2019 |
| Externally published | Yes |
Keywords
- Antimicrobial photodynamic inactivation
- Copper-cysteamine nanoparticles
- Gram-negative bacteria
- Gram-positive bacteria
- Reactive oxygen species
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Huang, L., Ma, L., Xuan, W., Zhen, X., Zheng, H., Chen, W., & Hamblin, M. R. (2019). Exploration of copper-cysteamine nanoparticles as a new type of agents for antimicrobial photodynamic inactivation. Journal of Biomedical Nanotechnology, 15(10), 2142-2148. https://doi.org/10.1166/jbn.2019.2829