TY - JOUR
T1 - Experimental approaches to modeling delirium in zebrafish (Danio rerio)
AU - Maslov, Gleb O.
AU - Kolesnikova, Tatyana O.
AU - Zabegalov, Konstantin N.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© Eco-Vector, 2022.
PY - 2022
Y1 - 2022
N2 - Delirium is an acute psychiatric syndrome characterized by impaired attention, perception and orientation in space. Albeit known for millennia, the mechanisms and risk factors of delirium remain poorly understood. Experimental animal models, especially rodents, become widely used to understand these pathogenetic aspects. However, a new model organism — zebrafish (Danio rerio) also has promise in this field. Discussed here, recent behavioral tests and protocols for zebrafish enable assessing their behavioral and cognitive function, and its experimental modulation by deliriant drugs and other factors.
AB - Delirium is an acute psychiatric syndrome characterized by impaired attention, perception and orientation in space. Albeit known for millennia, the mechanisms and risk factors of delirium remain poorly understood. Experimental animal models, especially rodents, become widely used to understand these pathogenetic aspects. However, a new model organism — zebrafish (Danio rerio) also has promise in this field. Discussed here, recent behavioral tests and protocols for zebrafish enable assessing their behavioral and cognitive function, and its experimental modulation by deliriant drugs and other factors.
KW - delirium
KW - experimental models
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85166753326&partnerID=8YFLogxK
U2 - 10.17816/RCF202177-183
DO - 10.17816/RCF202177-183
M3 - Article
AN - SCOPUS:85166753326
SN - 1683-4100
VL - 20
SP - 177
EP - 183
JO - Reviews on Clinical Pharmacology and Drug Therapy
JF - Reviews on Clinical Pharmacology and Drug Therapy
IS - 2
ER -