TY - JOUR
T1 - Epigallocatechin 3-gallate
T2 - From green tea to cancer therapeutics
AU - Alam, Manzar
AU - Ali, Sabeeha
AU - Ashraf, Ghulam Md
AU - Bilgrami, Anwar L.
AU - Yadav, Dharmendra Kumar
AU - Hassan, Md Imtaiyaz
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/6/15
Y1 - 2022/6/15
N2 - Epigallocatechin 3-gallate (EGCG) possesses various biological functions, including anti-cancer and anti-inflammatory properties. EGCG is an abundant polyphenolic component originating from green tea extract that has exhibited versatile bioactivities in combating several cancers. This review highlights the pharmacological features of EGCG and its therapeutic implications in cancer and other metabolic diseases. It modulates numerous signaling pathways, regulating cells' undesired survival and proliferation, thus imparting strong tumor chemopreventive and therapeutic effects. EGCG initiates cell death through the intrinsic pathway and causes inhibition of EGFR, STAT3, and ERK pathways in several cancers. EGCG alters and inhibits ERK1/2, NF-κB, and Akt-mediated signaling, altering the Bcl-2 family proteins ratio and activating caspases in tumor cells. This review focuses on anti-cancer, anti-oxidant, anti-inflammatory, anti-angiogenesis, and apoptotic effects of EGCG. We further highlighted the potential of EGCG in different types of cancer, emphasizing clinical trials formulations that further improve our understanding of the therapeutic management of cancer and inflammatory diseases.
AB - Epigallocatechin 3-gallate (EGCG) possesses various biological functions, including anti-cancer and anti-inflammatory properties. EGCG is an abundant polyphenolic component originating from green tea extract that has exhibited versatile bioactivities in combating several cancers. This review highlights the pharmacological features of EGCG and its therapeutic implications in cancer and other metabolic diseases. It modulates numerous signaling pathways, regulating cells' undesired survival and proliferation, thus imparting strong tumor chemopreventive and therapeutic effects. EGCG initiates cell death through the intrinsic pathway and causes inhibition of EGFR, STAT3, and ERK pathways in several cancers. EGCG alters and inhibits ERK1/2, NF-κB, and Akt-mediated signaling, altering the Bcl-2 family proteins ratio and activating caspases in tumor cells. This review focuses on anti-cancer, anti-oxidant, anti-inflammatory, anti-angiogenesis, and apoptotic effects of EGCG. We further highlighted the potential of EGCG in different types of cancer, emphasizing clinical trials formulations that further improve our understanding of the therapeutic management of cancer and inflammatory diseases.
KW - Cancer therapy
KW - Chemotherapy
KW - Drug discovery
KW - Epigallocatechin gallate
KW - Green tea extracts
KW - Natural products
KW - Signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=85122921169&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2022.132135
DO - 10.1016/j.foodchem.2022.132135
M3 - Article
C2 - 35063850
AN - SCOPUS:85122921169
SN - 0308-8146
VL - 379
JO - Food Chemistry
JF - Food Chemistry
M1 - 132135
ER -
