Enhancing the effects of transcranial magnetic stimulation with intravenously injected magnetic nanoparticles

Rongrong Li; Jun Wang; Xiaoya Yu; Pengfei Xu; Shuai Zhang; Jinhua Xu; Yongjie Bai; Zhengze Dai; Yuxiang Sun; Ruidong Ye; Xinfeng Liu; Gang Ruan; Gelin Xu

doi:10.1039/c9bm00178f

Enhancing the effects of transcranial magnetic stimulation with intravenously injected magnetic nanoparticles

Rongrong Li, Jun Wang, Xiaoya Yu, Pengfei Xu, Shuai Zhang, Jinhua Xu, Yongjie Bai, Zhengze Dai, Yuxiang Sun, Ruidong Ye, Xinfeng Liu, Gang Ruan^*, Gelin Xu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Transcranial magnetic stimulation (TMS) is a non-invasive and clinically approved method for treating neurological disorders. However, the relatively weak intracranial electric current induced by TMS is an obvious inferiority which can only produce limited treatment effects in clinical application. The present study aimed to investigate the possibility of enhancing the effects of TMS with intravenously administrated magnetic nanoparticles. To facilitate crossing of the blood-brain barrier (BBB), the superparamagnetic iron oxide nanoparticles (SPIONs) were coated with carboxylated chitosan and poly(ethylene glycol). To aid the nanoparticles in crossing the BBB and targeting the predesigned brain regions, an external permanent magnet was attached to the foreheads of the rats before the intravenous administration of SPIONs. The electrophysiological tests showed that the maximum MEP amplitude recorded in an individual rat was significantly higher in the SPIONs + magnet group than in the saline group (5.78 ± 2.54 vs. 1.80 ± 1.55 mV, P = 0.015). In the M1 region, biochemical tests detected that the number density of c-fos positive cells in the SPIONs + magnet group was 3.44 fold that of the saline group. These results suggest that intravenously injected SPIONs can enhance the effects of TMS in treating neurological disorders.

Original language	English
Pages (from-to)	2297-2307
Number of pages	11
Journal	Biomaterials Science
Volume	7
Issue number	6
DOIs	https://doi.org/10.1039/c9bm00178f
Publication status	Published - Jun 2019
Externally published	Yes

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title = "Enhancing the effects of transcranial magnetic stimulation with intravenously injected magnetic nanoparticles",

abstract = "Transcranial magnetic stimulation (TMS) is a non-invasive and clinically approved method for treating neurological disorders. However, the relatively weak intracranial electric current induced by TMS is an obvious inferiority which can only produce limited treatment effects in clinical application. The present study aimed to investigate the possibility of enhancing the effects of TMS with intravenously administrated magnetic nanoparticles. To facilitate crossing of the blood-brain barrier (BBB), the superparamagnetic iron oxide nanoparticles (SPIONs) were coated with carboxylated chitosan and poly(ethylene glycol). To aid the nanoparticles in crossing the BBB and targeting the predesigned brain regions, an external permanent magnet was attached to the foreheads of the rats before the intravenous administration of SPIONs. The electrophysiological tests showed that the maximum MEP amplitude recorded in an individual rat was significantly higher in the SPIONs + magnet group than in the saline group (5.78 ± 2.54 vs. 1.80 ± 1.55 mV, P = 0.015). In the M1 region, biochemical tests detected that the number density of c-fos positive cells in the SPIONs + magnet group was 3.44 fold that of the saline group. These results suggest that intravenously injected SPIONs can enhance the effects of TMS in treating neurological disorders.",

author = "Rongrong Li and Jun Wang and Xiaoya Yu and Pengfei Xu and Shuai Zhang and Jinhua Xu and Yongjie Bai and Zhengze Dai and Yuxiang Sun and Ruidong Ye and Xinfeng Liu and Gang Ruan and Gelin Xu",

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doi = "10.1039/c9bm00178f",

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AU - Li, Rongrong

AU - Wang, Jun

AU - Yu, Xiaoya

AU - Xu, Pengfei

AU - Zhang, Shuai

AU - Xu, Jinhua

AU - Bai, Yongjie

AU - Dai, Zhengze

AU - Sun, Yuxiang

AU - Ye, Ruidong

AU - Liu, Xinfeng

AU - Ruan, Gang

AU - Xu, Gelin

PY - 2019/6

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N2 - Transcranial magnetic stimulation (TMS) is a non-invasive and clinically approved method for treating neurological disorders. However, the relatively weak intracranial electric current induced by TMS is an obvious inferiority which can only produce limited treatment effects in clinical application. The present study aimed to investigate the possibility of enhancing the effects of TMS with intravenously administrated magnetic nanoparticles. To facilitate crossing of the blood-brain barrier (BBB), the superparamagnetic iron oxide nanoparticles (SPIONs) were coated with carboxylated chitosan and poly(ethylene glycol). To aid the nanoparticles in crossing the BBB and targeting the predesigned brain regions, an external permanent magnet was attached to the foreheads of the rats before the intravenous administration of SPIONs. The electrophysiological tests showed that the maximum MEP amplitude recorded in an individual rat was significantly higher in the SPIONs + magnet group than in the saline group (5.78 ± 2.54 vs. 1.80 ± 1.55 mV, P = 0.015). In the M1 region, biochemical tests detected that the number density of c-fos positive cells in the SPIONs + magnet group was 3.44 fold that of the saline group. These results suggest that intravenously injected SPIONs can enhance the effects of TMS in treating neurological disorders.

AB - Transcranial magnetic stimulation (TMS) is a non-invasive and clinically approved method for treating neurological disorders. However, the relatively weak intracranial electric current induced by TMS is an obvious inferiority which can only produce limited treatment effects in clinical application. The present study aimed to investigate the possibility of enhancing the effects of TMS with intravenously administrated magnetic nanoparticles. To facilitate crossing of the blood-brain barrier (BBB), the superparamagnetic iron oxide nanoparticles (SPIONs) were coated with carboxylated chitosan and poly(ethylene glycol). To aid the nanoparticles in crossing the BBB and targeting the predesigned brain regions, an external permanent magnet was attached to the foreheads of the rats before the intravenous administration of SPIONs. The electrophysiological tests showed that the maximum MEP amplitude recorded in an individual rat was significantly higher in the SPIONs + magnet group than in the saline group (5.78 ± 2.54 vs. 1.80 ± 1.55 mV, P = 0.015). In the M1 region, biochemical tests detected that the number density of c-fos positive cells in the SPIONs + magnet group was 3.44 fold that of the saline group. These results suggest that intravenously injected SPIONs can enhance the effects of TMS in treating neurological disorders.

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Enhancing the effects of transcranial magnetic stimulation with intravenously injected magnetic nanoparticles

Abstract

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