Efficient Synthesis of Substituted Morpholine Derivatives via an Indium(III)-catalyzed Reductive Etherification Reaction

Di Wang; Yafei Liu; Wei Zhu; Hong Shen; Haixia Liu; Lei Fu

doi:10.1246/cl.200142

Efficient Synthesis of Substituted Morpholine Derivatives via an Indium(III)-catalyzed Reductive Etherification Reaction

Di Wang, Yafei Liu, Wei Zhu, Hong Shen, Haixia Liu^*, Lei Fu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

An efficient synthesis of morpholine derivatives has been developed using indium(III)-catalyzed intramolecular reductive etherification reaction. This method allows the construction of various 2-substituted, and 2,3-, 2,5-, 2,6-disubstituted morpholines with good to excellent yields and high diastereoselectivity. In addition, this method demonstrates good compatibility with a broad range of functional groups.

Original language	English
Pages (from-to)	709-712
Number of pages	4
Journal	Chemistry Letters
Volume	49
Issue number	6
DOIs	https://doi.org/10.1246/cl.200142
Publication status	Published - Jun 2020
Externally published	Yes

Keywords

Morpholine , Indium bromide Reductive etherification

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10.1246/cl.200142

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abstract = "An efficient synthesis of morpholine derivatives has been developed using indium(III)-catalyzed intramolecular reductive etherification reaction. This method allows the construction of various 2-substituted, and 2,3-, 2,5-, 2,6-disubstituted morpholines with good to excellent yields and high diastereoselectivity. In addition, this method demonstrates good compatibility with a broad range of functional groups.",

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AU - Wang, Di

AU - Liu, Yafei

AU - Zhu, Wei

AU - Shen, Hong

AU - Liu, Haixia

AU - Fu, Lei

PY - 2020/6

Y1 - 2020/6

N2 - An efficient synthesis of morpholine derivatives has been developed using indium(III)-catalyzed intramolecular reductive etherification reaction. This method allows the construction of various 2-substituted, and 2,3-, 2,5-, 2,6-disubstituted morpholines with good to excellent yields and high diastereoselectivity. In addition, this method demonstrates good compatibility with a broad range of functional groups.

AB - An efficient synthesis of morpholine derivatives has been developed using indium(III)-catalyzed intramolecular reductive etherification reaction. This method allows the construction of various 2-substituted, and 2,3-, 2,5-, 2,6-disubstituted morpholines with good to excellent yields and high diastereoselectivity. In addition, this method demonstrates good compatibility with a broad range of functional groups.

KW - Morpholine , Indium bromide Reductive etherification

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DO - 10.1246/cl.200142

M3 - Article

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ER -

Efficient Synthesis of Substituted Morpholine Derivatives via an Indium(III)-catalyzed Reductive Etherification Reaction

Abstract

Keywords

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