TY - JOUR
T1 - Effects of Sr and Mg dopants on biological and mechanical properties of SiO2–CaO–P2O5 bioactive glass
AU - Sharifianjazi, Fariborz
AU - Moradi, Mostafa
AU - Abouchenari, Aliasghar
AU - Pakseresht, Amir Hossein
AU - Esmaeilkhanian, Amirhossein
AU - Shokouhimehr, Mohammadreza
AU - Shahedi Asl, Mehdi
N1 - Publisher Copyright:
© 2020 Elsevier Ltd and Techna Group S.r.l.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - In the present study, the effects of Sr and Mg were investigated on mechanical and biological properties of 58S bioactive glass (BG). SiO2-P2O5-CaO BG with different contents of Sr and Mg were synthesized via the sol-gel method and immersed in simulated body fluid (SBF) for several days to explore their biocompatibility. Precise analyses of the BG using X-ray powder diffraction, scanning electron microscopy, and transmission electron microscopy showed that the Mg-doped BG containing 8 wt % MgO possessed better biocompatibility. It was also found that mechanical properties of the BG could be improved by increasing the amounts of MgO and SrO. Both 5Sr-BG and 8Mg-BG samples did not exhibit any cytotoxicity while showing high alkaline phosphatase activity in comparison with control specimens. However, the Sr-doped BG sample including 5 wt % SrO demonstrated enhanced bioactivity and biocompatibility.
AB - In the present study, the effects of Sr and Mg were investigated on mechanical and biological properties of 58S bioactive glass (BG). SiO2-P2O5-CaO BG with different contents of Sr and Mg were synthesized via the sol-gel method and immersed in simulated body fluid (SBF) for several days to explore their biocompatibility. Precise analyses of the BG using X-ray powder diffraction, scanning electron microscopy, and transmission electron microscopy showed that the Mg-doped BG containing 8 wt % MgO possessed better biocompatibility. It was also found that mechanical properties of the BG could be improved by increasing the amounts of MgO and SrO. Both 5Sr-BG and 8Mg-BG samples did not exhibit any cytotoxicity while showing high alkaline phosphatase activity in comparison with control specimens. However, the Sr-doped BG sample including 5 wt % SrO demonstrated enhanced bioactivity and biocompatibility.
KW - Bioactive glass
KW - Bioactivity
KW - Biocompatibility
KW - Magnesium
KW - Mechanical properties
KW - Strontium
UR - http://www.scopus.com/inward/record.url?scp=85086516426&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2020.06.030
DO - 10.1016/j.ceramint.2020.06.030
M3 - Article
AN - SCOPUS:85086516426
SN - 0272-8842
VL - 46
SP - 22674
EP - 22682
JO - Ceramics International
JF - Ceramics International
IS - 14
ER -