TY - JOUR
T1 - Domain interplay concept in animal models of neuropsychiatric disorders
T2 - A new strategy for high-throughput neurophenotyping research
AU - Kalueff, Allan V.
AU - Ren-Patterson, Renee F.
AU - LaPorte, Justin L.
AU - Murphy, Dennis L.
PY - 2008/4/9
Y1 - 2008/4/9
N2 - Genetic and environmental factors play a key role in psychiatric disorders. While some disorders display exceptionally high heritability, others show gene × experience × personality interactions, contributing complexity to psychiatric phenotypes. As some brain disorders frequently overlap and co-occur (representing a continuum or spectrum of phenomena), modern psychiatry is shifting from "artificial" heterogeneity to the recognition of common elements in the pathogenesis of emotional, personality and behavioral disorders. Genetic animal models of these disorders represent an important direction of research, and are widely used to explore the role of different genes in brain mechanisms. Several concepts (such as endophenotypes, gene × environment interactions, and cross-species trait genetics) have been suggested for animal experimentation in this field. Here we develop a new concept based on targeting the complex interplay between different behavioral domains, meant to foster high-throughput phenotyping and integrative modeling of psychiatric disorders.
AB - Genetic and environmental factors play a key role in psychiatric disorders. While some disorders display exceptionally high heritability, others show gene × experience × personality interactions, contributing complexity to psychiatric phenotypes. As some brain disorders frequently overlap and co-occur (representing a continuum or spectrum of phenomena), modern psychiatry is shifting from "artificial" heterogeneity to the recognition of common elements in the pathogenesis of emotional, personality and behavioral disorders. Genetic animal models of these disorders represent an important direction of research, and are widely used to explore the role of different genes in brain mechanisms. Several concepts (such as endophenotypes, gene × environment interactions, and cross-species trait genetics) have been suggested for animal experimentation in this field. Here we develop a new concept based on targeting the complex interplay between different behavioral domains, meant to foster high-throughput phenotyping and integrative modeling of psychiatric disorders.
KW - Behavioral/psychiatric phenotypes
KW - Brain disorders
KW - Comorbidity
KW - Domain interplay
KW - Gene × environment interaction
KW - Genetic animal models
KW - Mutant and transgenic animals
UR - http://www.scopus.com/inward/record.url?scp=39149125460&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2007.11.011
DO - 10.1016/j.bbr.2007.11.011
M3 - Review article
C2 - 18164476
AN - SCOPUS:39149125460
SN - 0166-4328
VL - 188
SP - 243
EP - 249
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -