TY - JOUR
T1 - Developing translational biological psychiatry
T2 - Learning from history to build the future
AU - Demin, Konstantin
AU - Meshalkina, Darya
AU - Lakstygal, Anton
AU - Kalueff, Allan
N1 - Publisher Copyright:
© 2017 Demin et al.
PY - 2017
Y1 - 2017
N2 - Psychiatric disorders are among the most complex human disorders that, albeit often difficult to diagnose and treat, are widespread in modern society. Biological psychiatry studies biological functions of the central nervous system as mental disorders develop. Today’s biological psychiatry is facing multiple conceptual problems that prevent our deeper understanding of disease pathogenesis and delay the invention of new treatments. Thus, providing a historical context to this rapidly developing field may help scientists better understand the existing challenges and their potential solutions. Here, we discuss the main conceptual problems and paradigms of biological psychiatry, including the lack of reproducibility and/or valid theories, through an historical overview of its role in addressing theoretical and clinical questions. We propose a wider use of the translational approach in psychiatry to expand our analyses of psychiatric disorders to other species, and as a tool to create and further develop theories and concepts in this field.
AB - Psychiatric disorders are among the most complex human disorders that, albeit often difficult to diagnose and treat, are widespread in modern society. Biological psychiatry studies biological functions of the central nervous system as mental disorders develop. Today’s biological psychiatry is facing multiple conceptual problems that prevent our deeper understanding of disease pathogenesis and delay the invention of new treatments. Thus, providing a historical context to this rapidly developing field may help scientists better understand the existing challenges and their potential solutions. Here, we discuss the main conceptual problems and paradigms of biological psychiatry, including the lack of reproducibility and/or valid theories, through an historical overview of its role in addressing theoretical and clinical questions. We propose a wider use of the translational approach in psychiatry to expand our analyses of psychiatric disorders to other species, and as a tool to create and further develop theories and concepts in this field.
KW - Biological psychiatry
KW - Conceptual issues in psychiatry
KW - History of psychiatry
KW - Modern psychiatry
KW - Translational medicine
UR - http://www.scopus.com/inward/record.url?scp=85062963794&partnerID=8YFLogxK
U2 - 10.21638/11701/spbu03.2017.407
DO - 10.21638/11701/spbu03.2017.407
M3 - Article
AN - SCOPUS:85062963794
SN - 2542-2154
VL - 62
SP - 278
EP - 292
JO - Biological Communications
JF - Biological Communications
IS - 4
ER -