TY - JOUR
T1 - Developing 'integrative' zebrafish models of behavioral and metabolic disorders
AU - Nguyen, Michael
AU - Yang, Ester
AU - Neelkantan, Nikhil
AU - Mikhaylova, Alina
AU - Arnold, Raymond
AU - Poudel, Manoj K.
AU - Stewart, Adam Michael
AU - Kalueff, Allan V.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Recently, the pathophysiological overlap between metabolic and mental disorders has received increased recognition. Zebrafish (. Danio rerio) are rapidly becoming a popular model organism for translational biomedical research due to their genetic tractability, low cost, quick reproductive cycle, and ease of behavioral, pharmacological or genetic manipulation. High homology to mammalian physiology and the availability of well-developed assays also make the zebrafish an attractive organism for studying human disorders. Zebrafish neurobehavioral and endocrine phenotypes show promise for the use of zebrafish in studies of stress, obesity and related behavioral and metabolic disorders. Here, we discuss the parallels between zebrafish and other model species in stress and obesity physiology, as well as outline the available zebrafish models of weight gain, metabolic deficits, feeding, stress, anxiety and related behavioral disorders. Overall, zebrafish demonstrate a strong potential for modeling human behavioral and metabolic disorders, and their comorbidity.
AB - Recently, the pathophysiological overlap between metabolic and mental disorders has received increased recognition. Zebrafish (. Danio rerio) are rapidly becoming a popular model organism for translational biomedical research due to their genetic tractability, low cost, quick reproductive cycle, and ease of behavioral, pharmacological or genetic manipulation. High homology to mammalian physiology and the availability of well-developed assays also make the zebrafish an attractive organism for studying human disorders. Zebrafish neurobehavioral and endocrine phenotypes show promise for the use of zebrafish in studies of stress, obesity and related behavioral and metabolic disorders. Here, we discuss the parallels between zebrafish and other model species in stress and obesity physiology, as well as outline the available zebrafish models of weight gain, metabolic deficits, feeding, stress, anxiety and related behavioral disorders. Overall, zebrafish demonstrate a strong potential for modeling human behavioral and metabolic disorders, and their comorbidity.
KW - Comorbidity
KW - Metabolic disorders
KW - Neurobehavioral disorders
KW - Obesity
KW - Stress
KW - Zebrafish models
UR - http://www.scopus.com/inward/record.url?scp=84883262851&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2013.08.012
DO - 10.1016/j.bbr.2013.08.012
M3 - Review article
C2 - 23948218
AN - SCOPUS:84883262851
SN - 0166-4328
VL - 256
SP - 172
EP - 187
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -
