TY - JOUR
T1 - Developing better and more valid animal models of brain disorders
AU - Stewart, Adam Michael
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2013 Elsevier B.V.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Valid sensitive animal models are crucial for understanding the pathobiology of complex human disorders, such as anxiety, autism, depression and schizophrenia, which all have the 'spectrum' nature. Discussing new important strategic directions of research in this field, here we focus i) on cross-species validation of animal models, ii) ensuring their population (external) validity, and iii) the need to target the interplay between multiple disordered domains. We note that optimal animal models of brain disorders should target evolutionary conserved 'core' traits/domains and specifically mimic the clinically relevant inter-relationships between these domains.
AB - Valid sensitive animal models are crucial for understanding the pathobiology of complex human disorders, such as anxiety, autism, depression and schizophrenia, which all have the 'spectrum' nature. Discussing new important strategic directions of research in this field, here we focus i) on cross-species validation of animal models, ii) ensuring their population (external) validity, and iii) the need to target the interplay between multiple disordered domains. We note that optimal animal models of brain disorders should target evolutionary conserved 'core' traits/domains and specifically mimic the clinically relevant inter-relationships between these domains.
KW - Animal model
KW - Biological psychiatry
KW - Domain interplay
KW - Model validity
KW - Translational neuroscience
UR - http://www.scopus.com/inward/record.url?scp=84910068874&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2013.12.024
DO - 10.1016/j.bbr.2013.12.024
M3 - Review article
C2 - 24384129
AN - SCOPUS:84910068874
SN - 0166-4328
VL - 276
SP - 28
EP - 31
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -