Despair-like behavior in fish based on the zebrafish (Danio rerio)

David S. Galstyan; Tatyana O. Kolesnikova; Yurii M. Kositsyn; Konstantin N. Zabegalov; Mariya A. Gubaidullina; Gleb O. Maslov; Konstantin A. Demin; Allan V. Kalueff

doi:10.17816/RCF202157-162

Despair-like behavior in fish based on the zebrafish (Danio rerio)

David S. Galstyan, Tatyana O. Kolesnikova, Yurii M. Kositsyn, Konstantin N. Zabegalov, Mariya A. Gubaidullina, Gleb O. Maslov, Konstantin A. Demin, Allan V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The zebrafish tail immobilization test is a relatively new method for analyzing zebrafish behavior, based on the paradigm of learned helplessness, when the animal is exposed to an uncontrollable stressor, and soon abandons all attempts to avoid the aversive stimulus, adopting a posture of immobility. As an aversive stimulus acts restraining fish tail in a viscose sponge, without restricting the mobility of the lateral fins and the front of the body. The zebrafish tail immobilization test is suitable for detecting depressive-like ‘despair’ behavior in zebrafish, paralleling clinical apathy and lethargy in depression.

Original language	English
Pages (from-to)	157-162
Number of pages	6
Journal	Reviews on Clinical Pharmacology and Drug Therapy
Volume	20
Issue number	2
DOIs	https://doi.org/10.17816/RCF202157-162
Publication status	Published - 2022
Externally published	Yes

Keywords

antidepressants
despair
learned helplessness
tail immobilization
zebrafish

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10.17816/RCF202157-162

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abstract = "The zebrafish tail immobilization test is a relatively new method for analyzing zebrafish behavior, based on the paradigm of learned helplessness, when the animal is exposed to an uncontrollable stressor, and soon abandons all attempts to avoid the aversive stimulus, adopting a posture of immobility. As an aversive stimulus acts restraining fish tail in a viscose sponge, without restricting the mobility of the lateral fins and the front of the body. The zebrafish tail immobilization test is suitable for detecting depressive-like {\textquoteleft}despair{\textquoteright} behavior in zebrafish, paralleling clinical apathy and lethargy in depression.",

keywords = "antidepressants, despair, learned helplessness, tail immobilization, zebrafish",

author = "Galstyan, {David S.} and Kolesnikova, {Tatyana O.} and Kositsyn, {Yurii M.} and Zabegalov, {Konstantin N.} and Gubaidullina, {Mariya A.} and Maslov, {Gleb O.} and Demin, {Konstantin A.} and Kalueff, {Allan V.}",

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language = "English",

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T1 - Despair-like behavior in fish based on the zebrafish (Danio rerio)

AU - Galstyan, David S.

AU - Kolesnikova, Tatyana O.

AU - Kositsyn, Yurii M.

AU - Zabegalov, Konstantin N.

AU - Gubaidullina, Mariya A.

AU - Maslov, Gleb O.

AU - Demin, Konstantin A.

AU - Kalueff, Allan V.

N1 - Publisher Copyright: © Eco-Vector, 2022.

PY - 2022

Y1 - 2022

N2 - The zebrafish tail immobilization test is a relatively new method for analyzing zebrafish behavior, based on the paradigm of learned helplessness, when the animal is exposed to an uncontrollable stressor, and soon abandons all attempts to avoid the aversive stimulus, adopting a posture of immobility. As an aversive stimulus acts restraining fish tail in a viscose sponge, without restricting the mobility of the lateral fins and the front of the body. The zebrafish tail immobilization test is suitable for detecting depressive-like ‘despair’ behavior in zebrafish, paralleling clinical apathy and lethargy in depression.

AB - The zebrafish tail immobilization test is a relatively new method for analyzing zebrafish behavior, based on the paradigm of learned helplessness, when the animal is exposed to an uncontrollable stressor, and soon abandons all attempts to avoid the aversive stimulus, adopting a posture of immobility. As an aversive stimulus acts restraining fish tail in a viscose sponge, without restricting the mobility of the lateral fins and the front of the body. The zebrafish tail immobilization test is suitable for detecting depressive-like ‘despair’ behavior in zebrafish, paralleling clinical apathy and lethargy in depression.

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KW - despair

KW - learned helplessness

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Despair-like behavior in fish based on the zebrafish (Danio rerio)

Abstract

Keywords

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