TY - JOUR
T1 - Design of gold nanoparticles for magnetic resonance imaging
AU - Debouttière, Pierre Jean
AU - Roux, Stéphane
AU - Vocanson, Francis
AU - Billotey, Claire
AU - Beuf, Olivier
AU - Favre-Réguillon, Alain
AU - Lin, Yi
AU - Pellet-Rostaing, Stéphane
AU - Lamartine, Roger
AU - Perriat, Pascal
AU - Tillement, Olivier
PY - 2006/12/4
Y1 - 2006/12/4
N2 - Improving the sensitivity of magnetic resonance imaging (MRI), a powerful non-invasive medical imaging technique, requires the development of novel contrast agents with a higher efficiency than gadolinium chelates such as DTPA:Gd (DTPA: diethylenetriaminepentaacetic acid) that are currently used for clinical diagnosis. To achieve this objective, the strategy that we have explored involves the use of gold nanoparticles as carriers for gadolinium chelates. These nanoparticles are obtained by reducing a gold salt in the presence of a dithiolated derivative of DTPA. Characterization of these particles by transmission electron microscopy (TEM). X-ray diffraction (XRD), thermogravimetric analysis (TGA), colorimetric titration, and X-ray photoelectron spectroscopy (XPS) reveals the presence of a multilayered shell containing about 150 ligands on 2-2.5 nm sized particles. These particles exhibit a high relaxivity (r1=585 mM-1 s-1 as compared to 3.0mM-1s-1 for DTPA:Gd), rendering them very attractive as contrast agents for MRI.
AB - Improving the sensitivity of magnetic resonance imaging (MRI), a powerful non-invasive medical imaging technique, requires the development of novel contrast agents with a higher efficiency than gadolinium chelates such as DTPA:Gd (DTPA: diethylenetriaminepentaacetic acid) that are currently used for clinical diagnosis. To achieve this objective, the strategy that we have explored involves the use of gold nanoparticles as carriers for gadolinium chelates. These nanoparticles are obtained by reducing a gold salt in the presence of a dithiolated derivative of DTPA. Characterization of these particles by transmission electron microscopy (TEM). X-ray diffraction (XRD), thermogravimetric analysis (TGA), colorimetric titration, and X-ray photoelectron spectroscopy (XPS) reveals the presence of a multilayered shell containing about 150 ligands on 2-2.5 nm sized particles. These particles exhibit a high relaxivity (r1=585 mM-1 s-1 as compared to 3.0mM-1s-1 for DTPA:Gd), rendering them very attractive as contrast agents for MRI.
UR - http://www.scopus.com/inward/record.url?scp=33845911755&partnerID=8YFLogxK
U2 - 10.1002/adfm.200600242
DO - 10.1002/adfm.200600242
M3 - Article
AN - SCOPUS:33845911755
SN - 1616-301X
VL - 16
SP - 2330
EP - 2339
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 18
ER -