Design and simulation of proportional biological operational Mu-circuit

Dechang Xu; Zhipeng Cai; Ke Liu; Xiangmiao Zeng; Yujing Ouyang; Cuihong Dai; Aiju Hou; Dayou Cheng; Jianzhong Li

doi:10.1109/TNB.2015.2403871

Design and simulation of proportional biological operational Mu-circuit

Dechang Xu^*, Zhipeng Cai, Ke Liu, Xiangmiao Zeng, Yujing Ouyang, Cuihong Dai, Aiju Hou, Dayou Cheng, Jianzhong Li

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device - Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that will be possible to regulate input-output proportionally by manipulating the RBS of hrpR, hrpS, tetR and output gene and used in the sensing of environmental weak signals such as dioxins.

Original language	English
Article number	7042316
Pages (from-to)	248-253
Number of pages	6
Journal	IEEE Transactions on Nanobioscience
Volume	14
Issue number	2
DOIs	https://doi.org/10.1109/TNB.2015.2403871
Publication status	Published - 1 Mar 2015
Externally published	Yes

Keywords

Modeling
proportional regulation
simulation

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10.1109/TNB.2015.2403871

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Xu, D., Cai, Z., Liu, K., Zeng, X., Ouyang, Y., Dai, C., Hou, A., Cheng, D., & Li, J. (2015). Design and simulation of proportional biological operational Mu-circuit. IEEE Transactions on Nanobioscience, 14(2), 248-253. Article 7042316. https://doi.org/10.1109/TNB.2015.2403871

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abstract = "It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device - Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that will be possible to regulate input-output proportionally by manipulating the RBS of hrpR, hrpS, tetR and output gene and used in the sensing of environmental weak signals such as dioxins.",

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author = "Dechang Xu and Zhipeng Cai and Ke Liu and Xiangmiao Zeng and Yujing Ouyang and Cuihong Dai and Aiju Hou and Dayou Cheng and Jianzhong Li",

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AU - Xu, Dechang

AU - Cai, Zhipeng

AU - Liu, Ke

AU - Zeng, Xiangmiao

AU - Ouyang, Yujing

AU - Dai, Cuihong

AU - Hou, Aiju

AU - Cheng, Dayou

AU - Li, Jianzhong

PY - 2015/3/1

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N2 - It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device - Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that will be possible to regulate input-output proportionally by manipulating the RBS of hrpR, hrpS, tetR and output gene and used in the sensing of environmental weak signals such as dioxins.

AB - It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device - Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that will be possible to regulate input-output proportionally by manipulating the RBS of hrpR, hrpS, tetR and output gene and used in the sensing of environmental weak signals such as dioxins.

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KW - simulation

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Design and simulation of proportional biological operational Mu-circuit

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Keywords

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