TY - JOUR
T1 - Cytotoxic T-lymphocyte antigen 4 gene polymorphisms are associated with latent autoimmune diabetes in adults
AU - Douroudis, K.
AU - Prans, E.
AU - Kisand, K.
AU - Nemvalts, V.
AU - Uibo, R.
N1 - Funding Information:
We thank Dr. K. Haller and Dr. L. Salur from the Department of Immunology, University of Tartu for help in preparing patients data and testing of autoantibodies. We would like also to thank Professor J. Ilonen from University of Turku for the fruitful discussion. The study was supported by Estonian Science Foundation Grants no. 6514 and 5203, and partly by INNOVE SA.
PY - 2009/5
Y1 - 2009/5
N2 - Background: Cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule is an important regulator of T cell activation involved in the down-regulation of immune response. Polymorphisms within the CTLA-4 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. Methods: In order to evaluate the impact of allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the CT60 A/G SNP and the CTBC217_1 C/T SNP were studied in a population of Estonian origin, including 61 LADA patients and 230 controls. Results: It was found that the CT60 GG genotype (p = 0.004) and the CTBC217_1 TT genotype (p = 0.007) were significant associated with LADA. Conclusions: Our investigation revealed that not only type 1 diabetes but also LADA is associated with CTLA-4 gene polymorphisms. The role of CTLA-4 gene in the pathogenesis of LADA is open and needs further investigations.
AB - Background: Cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule is an important regulator of T cell activation involved in the down-regulation of immune response. Polymorphisms within the CTLA-4 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. Methods: In order to evaluate the impact of allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the CT60 A/G SNP and the CTBC217_1 C/T SNP were studied in a population of Estonian origin, including 61 LADA patients and 230 controls. Results: It was found that the CT60 GG genotype (p = 0.004) and the CTBC217_1 TT genotype (p = 0.007) were significant associated with LADA. Conclusions: Our investigation revealed that not only type 1 diabetes but also LADA is associated with CTLA-4 gene polymorphisms. The role of CTLA-4 gene in the pathogenesis of LADA is open and needs further investigations.
KW - CTLA-4 (cytotoxic T lymphocyte antigen-4)
KW - LADA (latent autoimmune diabetes in adults)
KW - SNP (single nucleotide polymorphism)
UR - http://www.scopus.com/inward/record.url?scp=64849101450&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2009.03.036
DO - 10.1016/j.cca.2009.03.036
M3 - Article
C2 - 19332045
AN - SCOPUS:64849101450
SN - 0009-8981
VL - 403
SP - 226
EP - 228
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 1-2
ER -
