Xiang, J., Zhang, X., Wang, D., Li, J., Li, Q., Wang, Q., Ding, Y., Chen, T., Sun, Y., Bao, S., Chen, J., Li, D., Wang, L., & Chen, Y. (2020). Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile. Chemical Communications, 56(75), 11018-11021. https://doi.org/10.1039/c9cc07573a
Xiang, Junhong ; Zhang, Xuemei ; Wang, Dehong et al. / Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile. In: Chemical Communications. 2020 ; Vol. 56, No. 75. pp. 11018-11021.
@article{20451bf40450459fa46bc5334224943d,
title = "Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile",
abstract = "Stepwise modification of ovatodiolide revealed a prodrug, NMP-diepoxyovatodiolide, which can provide sustained release of an active compound, substantial metabolic stability and a unique accumulation profile in the liver. Besides, NMP-diepoxyovatodiolide demonstrated therapeutic benefits in an acute autoimmune hepatitis mouse model and a broad safety window. Therefore, NMP-diepoxyovatodiolide is a very promising candidate for further development of liver-related drugs.",
author = "Junhong Xiang and Xuemei Zhang and Dehong Wang and Jiaxin Li and Qiuying Li and Qin Wang and Yahui Ding and Tianyang Chen and Yuanjun Sun and Shiqi Bao and Jing Chen and Dongmei Li and Liang Wang and Yue Chen",
note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",
year = "2020",
month = sep,
day = "25",
doi = "10.1039/c9cc07573a",
language = "English",
volume = "56",
pages = "11018--11021",
journal = "Chemical Communications",
issn = "1359-7345",
number = "75",
}
Xiang, J, Zhang, X, Wang, D, Li, J, Li, Q, Wang, Q, Ding, Y, Chen, T, Sun, Y, Bao, S, Chen, J, Li, D, Wang, L & Chen, Y 2020, 'Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile', Chemical Communications, vol. 56, no. 75, pp. 11018-11021. https://doi.org/10.1039/c9cc07573a
Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile. / Xiang, Junhong; Zhang, Xuemei; Wang, Dehong et al.
In:
Chemical Communications, Vol. 56, No. 75, 25.09.2020, p. 11018-11021.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile
AU - Xiang, Junhong
AU - Zhang, Xuemei
AU - Wang, Dehong
AU - Li, Jiaxin
AU - Li, Qiuying
AU - Wang, Qin
AU - Ding, Yahui
AU - Chen, Tianyang
AU - Sun, Yuanjun
AU - Bao, Shiqi
AU - Chen, Jing
AU - Li, Dongmei
AU - Wang, Liang
AU - Chen, Yue
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2020.
PY - 2020/9/25
Y1 - 2020/9/25
N2 - Stepwise modification of ovatodiolide revealed a prodrug, NMP-diepoxyovatodiolide, which can provide sustained release of an active compound, substantial metabolic stability and a unique accumulation profile in the liver. Besides, NMP-diepoxyovatodiolide demonstrated therapeutic benefits in an acute autoimmune hepatitis mouse model and a broad safety window. Therefore, NMP-diepoxyovatodiolide is a very promising candidate for further development of liver-related drugs.
AB - Stepwise modification of ovatodiolide revealed a prodrug, NMP-diepoxyovatodiolide, which can provide sustained release of an active compound, substantial metabolic stability and a unique accumulation profile in the liver. Besides, NMP-diepoxyovatodiolide demonstrated therapeutic benefits in an acute autoimmune hepatitis mouse model and a broad safety window. Therefore, NMP-diepoxyovatodiolide is a very promising candidate for further development of liver-related drugs.
UR - http://www.scopus.com/inward/record.url?scp=85091469978&partnerID=8YFLogxK
U2 - 10.1039/c9cc07573a
DO - 10.1039/c9cc07573a
M3 - Article
C2 - 32856652
AN - SCOPUS:85091469978
SN - 1359-7345
VL - 56
SP - 11018
EP - 11021
JO - Chemical Communications
JF - Chemical Communications
IS - 75
ER -
Xiang J, Zhang X, Wang D, Li J, Li Q, Wang Q et al. Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile. Chemical Communications. 2020 Sept 25;56(75):11018-11021. doi: 10.1039/c9cc07573a
