Mechanism of action of antiepileptic drugs

Haider Ali; Naushad Ahmad Khan; Mirza Masroor Ali Beg; Mohammed Zahed Sarwar; Nurida Kemelbek Kyzy; Tilekeeva Ulankul Muktarovna; Kudaibergen Osmonaliev; Faez Iqbal Khan; Muhammed Burak Ay

doi:10.1016/B978-0-323-99855-0.00008-7

Mechanism of action of antiepileptic drugs

Haider Ali, Naushad Ahmad Khan, Mirza Masroor Ali Beg, Mohammed Zahed Sarwar, Nurida Kemelbek Kyzy, Tilekeeva Ulankul Muktarovna, Kudaibergen Osmonaliev, Faez Iqbal Khan, Muhammed Burak Ay

Department of Biological Sciences

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

Abstract

About 1% of the general population suffers from epilepsy, which may leave them severely handicapped. Antiepileptic medications have a major role in the treatment of seizures in people with epilepsy (AEDs). Some of the most common drugs used to treat epilepsy have included phenobarbital, carbamazepine, valproic acid, and phenytoin. There are many AEDs licensed by the FDA since 1993 for use in the treatment of epilepsy. The kind of seizure, clinical activity range, side effect profile, and patient variables such as age, comorbidities, and concomitant medical therapies all factor into the decision to use an AED. It is common for AEDs with broad-spectrum efficacy to have many molecular targets. This chapter will examine the potential mechanisms of action of commercialized AEDs in the United States and evaluate the future of AEDs under development.

Original language	English
Title of host publication	How Synthetic Drugs Work
Subtitle of host publication	Insights into Molecular Pharmacology of Classic and New Pharmaceuticals
Publisher	Elsevier
Pages	177-193
Number of pages	17
ISBN (Electronic)	9780323998550
ISBN (Print)	9780323913683
DOIs	https://doi.org/10.1016/B978-0-323-99855-0.00008-7
Publication status	Published - 1 Jan 2023

Keywords

anticonvulsant drugs
epilepsy
mechanism of action
seizures

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10.1016/B978-0-323-99855-0.00008-7

Cite this

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abstract = "About 1% of the general population suffers from epilepsy, which may leave them severely handicapped. Antiepileptic medications have a major role in the treatment of seizures in people with epilepsy (AEDs). Some of the most common drugs used to treat epilepsy have included phenobarbital, carbamazepine, valproic acid, and phenytoin. There are many AEDs licensed by the FDA since 1993 for use in the treatment of epilepsy. The kind of seizure, clinical activity range, side effect profile, and patient variables such as age, comorbidities, and concomitant medical therapies all factor into the decision to use an AED. It is common for AEDs with broad-spectrum efficacy to have many molecular targets. This chapter will examine the potential mechanisms of action of commercialized AEDs in the United States and evaluate the future of AEDs under development.",

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AU - Muktarovna, Tilekeeva Ulankul

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AU - Khan, Faez Iqbal

AU - Ay, Muhammed Burak

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AB - About 1% of the general population suffers from epilepsy, which may leave them severely handicapped. Antiepileptic medications have a major role in the treatment of seizures in people with epilepsy (AEDs). Some of the most common drugs used to treat epilepsy have included phenobarbital, carbamazepine, valproic acid, and phenytoin. There are many AEDs licensed by the FDA since 1993 for use in the treatment of epilepsy. The kind of seizure, clinical activity range, side effect profile, and patient variables such as age, comorbidities, and concomitant medical therapies all factor into the decision to use an AED. It is common for AEDs with broad-spectrum efficacy to have many molecular targets. This chapter will examine the potential mechanisms of action of commercialized AEDs in the United States and evaluate the future of AEDs under development.

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Mechanism of action of antiepileptic drugs

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Keywords

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