Mechanism of action of antiepileptic drugs

Haider Ali; Naushad Ahmad Khan; Mirza Masroor Ali Beg; Mohammed Zahed Sarwar; Nurida Kemelbek Kyzy; Tilekeeva Ulankul Muktarovna; Kudaibergen Osmonaliev; Faez Iqbal Khan; Muhammed Burak Ay

doi:10.1016/B978-0-323-99855-0.00008-7

Mechanism of action of antiepileptic drugs

Haider Ali, Naushad Ahmad Khan, Mirza Masroor Ali Beg, Mohammed Zahed Sarwar, Nurida Kemelbek Kyzy, Tilekeeva Ulankul Muktarovna, Kudaibergen Osmonaliev, Faez Iqbal Khan, Muhammed Burak Ay

Department of Biosciences and Bioinformatics

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

About 1% of the general population suffers from epilepsy, which may leave them severely handicapped. Antiepileptic medications have a major role in the treatment of seizures in people with epilepsy (AEDs). Some of the most common drugs used to treat epilepsy have included phenobarbital, carbamazepine, valproic acid, and phenytoin. There are many AEDs licensed by the FDA since 1993 for use in the treatment of epilepsy. The kind of seizure, clinical activity range, side effect profile, and patient variables such as age, comorbidities, and concomitant medical therapies all factor into the decision to use an AED. It is common for AEDs with broad-spectrum efficacy to have many molecular targets. This chapter will examine the potential mechanisms of action of commercialized AEDs in the United States and evaluate the future of AEDs under development.

Original language	English
Title of host publication	How Synthetic Drugs Work
Subtitle of host publication	Insights into Molecular Pharmacology of Classic and New Pharmaceuticals
Publisher	Elsevier
Pages	177-193
Number of pages	17
ISBN (Electronic)	9780323998550
ISBN (Print)	9780323913683
DOIs	https://doi.org/10.1016/B978-0-323-99855-0.00008-7
Publication status	Published - 1 Jan 2023

Keywords

anticonvulsant drugs
epilepsy
mechanism of action
seizures

Access to Document

10.1016/B978-0-323-99855-0.00008-7

Cite this

@inbook{723090f9ea974d2887658e1d40819853,

title = "Mechanism of action of antiepileptic drugs",

abstract = "About 1% of the general population suffers from epilepsy, which may leave them severely handicapped. Antiepileptic medications have a major role in the treatment of seizures in people with epilepsy (AEDs). Some of the most common drugs used to treat epilepsy have included phenobarbital, carbamazepine, valproic acid, and phenytoin. There are many AEDs licensed by the FDA since 1993 for use in the treatment of epilepsy. The kind of seizure, clinical activity range, side effect profile, and patient variables such as age, comorbidities, and concomitant medical therapies all factor into the decision to use an AED. It is common for AEDs with broad-spectrum efficacy to have many molecular targets. This chapter will examine the potential mechanisms of action of commercialized AEDs in the United States and evaluate the future of AEDs under development.",

keywords = "anticonvulsant drugs, epilepsy, mechanism of action, seizures",

author = "Haider Ali and Khan, {Naushad Ahmad} and Beg, {Mirza Masroor Ali} and Sarwar, {Mohammed Zahed} and {Kemelbek Kyzy}, Nurida and Muktarovna, {Tilekeeva Ulankul} and Kudaibergen Osmonaliev and Khan, {Faez Iqbal} and Ay, {Muhammed Burak}",

year = "2023",

month = jan,

day = "1",

doi = "10.1016/B978-0-323-99855-0.00008-7",

language = "English",

isbn = "9780323913683",

pages = "177--193",

booktitle = "How Synthetic Drugs Work",

publisher = "Elsevier",

}

TY - CHAP

T1 - Mechanism of action of antiepileptic drugs

AU - Ali, Haider

AU - Khan, Naushad Ahmad

AU - Beg, Mirza Masroor Ali

AU - Sarwar, Mohammed Zahed

AU - Kemelbek Kyzy, Nurida

AU - Muktarovna, Tilekeeva Ulankul

AU - Osmonaliev, Kudaibergen

AU - Khan, Faez Iqbal

AU - Ay, Muhammed Burak

PY - 2023/1/1

Y1 - 2023/1/1

N2 - About 1% of the general population suffers from epilepsy, which may leave them severely handicapped. Antiepileptic medications have a major role in the treatment of seizures in people with epilepsy (AEDs). Some of the most common drugs used to treat epilepsy have included phenobarbital, carbamazepine, valproic acid, and phenytoin. There are many AEDs licensed by the FDA since 1993 for use in the treatment of epilepsy. The kind of seizure, clinical activity range, side effect profile, and patient variables such as age, comorbidities, and concomitant medical therapies all factor into the decision to use an AED. It is common for AEDs with broad-spectrum efficacy to have many molecular targets. This chapter will examine the potential mechanisms of action of commercialized AEDs in the United States and evaluate the future of AEDs under development.

AB - About 1% of the general population suffers from epilepsy, which may leave them severely handicapped. Antiepileptic medications have a major role in the treatment of seizures in people with epilepsy (AEDs). Some of the most common drugs used to treat epilepsy have included phenobarbital, carbamazepine, valproic acid, and phenytoin. There are many AEDs licensed by the FDA since 1993 for use in the treatment of epilepsy. The kind of seizure, clinical activity range, side effect profile, and patient variables such as age, comorbidities, and concomitant medical therapies all factor into the decision to use an AED. It is common for AEDs with broad-spectrum efficacy to have many molecular targets. This chapter will examine the potential mechanisms of action of commercialized AEDs in the United States and evaluate the future of AEDs under development.

KW - anticonvulsant drugs

KW - epilepsy

KW - mechanism of action

KW - seizures

UR - http://www.scopus.com/inward/record.url?scp=85145127455&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-99855-0.00008-7

DO - 10.1016/B978-0-323-99855-0.00008-7

M3 - Chapter

AN - SCOPUS:85145127455

SN - 9780323913683

SP - 177

EP - 193

BT - How Synthetic Drugs Work

PB - Elsevier

ER -

Mechanism of action of antiepileptic drugs

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this