TY - JOUR
T1 - Biological activities of QIAPI 1 as a melanin precursor and its therapeutic effects in Wistar rats exposed to arsenic poisoning
AU - Solís-Herrera, Arturo
AU - Ashraf, Ghulam M.
AU - María del Esparza, C. A.
AU - Arias, Ruth I.S.
AU - Bachurin, Sergei O.
AU - Barreto, George E.
AU - Aliev, Gjumrakch
N1 - Publisher Copyright:
© 2015 Bentham Science Publishers.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - The chemical process initiated by QIAPI 1 has been deemed to be the most important biological reaction associated with human photosynthesis, and possibly neuroprotective effects under various inflammatory events. However, the detailed biological activities of QIAPI 1 as a melanin precursor are still unknown. In the present work, cytotoxicity test was done by MTT assay to determine cell viability of various cell lines (WI-38, A549, HS 683) like proliferation tests and its effect on cytokine production. Arsenic poisoning is an often-unrecognized cause of renal insufficiency. No prophylactic and/or therapeutic compounds have shown promising results against kidney diseases. The pathogenesis of Arsenicinduced nephropathy is not clear. Arsenic, as itself, does not degrade over time in the environment, and its accumulation may induce toxic effects. In this study, we also report the histological findings of the kidney in 3 groups of Wistar rats, a control group, a group exposed to arsenic in the water; and a group exposed to arsenic and treated with QIAPI 1 simultaneously. The findings of the current evidence indicates a potential therapeutic ability of QIAPI 1.
AB - The chemical process initiated by QIAPI 1 has been deemed to be the most important biological reaction associated with human photosynthesis, and possibly neuroprotective effects under various inflammatory events. However, the detailed biological activities of QIAPI 1 as a melanin precursor are still unknown. In the present work, cytotoxicity test was done by MTT assay to determine cell viability of various cell lines (WI-38, A549, HS 683) like proliferation tests and its effect on cytokine production. Arsenic poisoning is an often-unrecognized cause of renal insufficiency. No prophylactic and/or therapeutic compounds have shown promising results against kidney diseases. The pathogenesis of Arsenicinduced nephropathy is not clear. Arsenic, as itself, does not degrade over time in the environment, and its accumulation may induce toxic effects. In this study, we also report the histological findings of the kidney in 3 groups of Wistar rats, a control group, a group exposed to arsenic in the water; and a group exposed to arsenic and treated with QIAPI 1 simultaneously. The findings of the current evidence indicates a potential therapeutic ability of QIAPI 1.
KW - Arsenic
KW - Cytotoxicity
KW - Human photosynthesis
KW - Melanin
KW - QIAPI 1
UR - http://www.scopus.com/inward/record.url?scp=84930700953&partnerID=8YFLogxK
U2 - 10.2174/1871524915666150424113831
DO - 10.2174/1871524915666150424113831
M3 - Article
C2 - 25909193
AN - SCOPUS:84930700953
SN - 1871-5249
VL - 15
SP - 99
EP - 108
JO - Central Nervous System Agents in Medicinal Chemistry
JF - Central Nervous System Agents in Medicinal Chemistry
IS - 2
ER -
