Stewart, A., Riehl, R., Wong, K., Green, J., Cosgrove, J., Vollmer, K., Kyzar, E., Hart, P., Allain, A., Cachat, J., Gaikwad, S., Hook, M., Rhymes, K., Newman, A., Utterback, E., Chang, K., & Kalueff, A. V. (2011). Behavioral effects of MDMA ('ecstasy') on adult zebrafish. Behavioural Pharmacology, 22(3), 275-280. https://doi.org/10.1097/FBP.0b013e328345f758
Stewart, Adam ; Riehl, Russell ; Wong, Keith et al. / Behavioral effects of MDMA ('ecstasy') on adult zebrafish. In: Behavioural Pharmacology. 2011 ; Vol. 22, No. 3. pp. 275-280.
@article{b23cd6be28244583a99de3efb338762f,
title = "Behavioral effects of MDMA ('ecstasy') on adult zebrafish",
abstract = "3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.",
keywords = "3,4-methylenedioxymethamphetamine, anxiety, locomotion, novelty-based paradigms, psychedelic hallucinogenic drugs, zebrafish",
author = "Adam Stewart and Russell Riehl and Keith Wong and Jeremy Green and Jessica Cosgrove and Karoly Vollmer and Evan Kyzar and Peter Hart and Alexander Allain and Jonathan Cachat and Siddharth Gaikwad and Molly Hook and Kate Rhymes and Alan Newman and Eli Utterback and Katie Chang and Kalueff, {Allan V.}",
year = "2011",
month = jun,
doi = "10.1097/FBP.0b013e328345f758",
language = "English",
volume = "22",
pages = "275--280",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
number = "3",
}
Stewart, A, Riehl, R, Wong, K, Green, J, Cosgrove, J, Vollmer, K, Kyzar, E, Hart, P, Allain, A, Cachat, J, Gaikwad, S, Hook, M, Rhymes, K, Newman, A, Utterback, E, Chang, K & Kalueff, AV 2011, 'Behavioral effects of MDMA ('ecstasy') on adult zebrafish', Behavioural Pharmacology, vol. 22, no. 3, pp. 275-280. https://doi.org/10.1097/FBP.0b013e328345f758
Behavioral effects of MDMA ('ecstasy') on adult zebrafish. / Stewart, Adam; Riehl, Russell; Wong, Keith et al.
In:
Behavioural Pharmacology, Vol. 22, No. 3, 06.2011, p. 275-280.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Behavioral effects of MDMA ('ecstasy') on adult zebrafish
AU - Stewart, Adam
AU - Riehl, Russell
AU - Wong, Keith
AU - Green, Jeremy
AU - Cosgrove, Jessica
AU - Vollmer, Karoly
AU - Kyzar, Evan
AU - Hart, Peter
AU - Allain, Alexander
AU - Cachat, Jonathan
AU - Gaikwad, Siddharth
AU - Hook, Molly
AU - Rhymes, Kate
AU - Newman, Alan
AU - Utterback, Eli
AU - Chang, Katie
AU - Kalueff, Allan V.
PY - 2011/6
Y1 - 2011/6
N2 - 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.
AB - 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.
KW - 3,4-methylenedioxymethamphetamine
KW - anxiety
KW - locomotion
KW - novelty-based paradigms
KW - psychedelic hallucinogenic drugs
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=79955472632&partnerID=8YFLogxK
U2 - 10.1097/FBP.0b013e328345f758
DO - 10.1097/FBP.0b013e328345f758
M3 - Article
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AN - SCOPUS:79955472632
SN - 0955-8810
VL - 22
SP - 275
EP - 280
JO - Behavioural Pharmacology
JF - Behavioural Pharmacology
IS - 3
ER -
Stewart A, Riehl R, Wong K, Green J, Cosgrove J, Vollmer K et al. Behavioral effects of MDMA ('ecstasy') on adult zebrafish. Behavioural Pharmacology. 2011 Jun;22(3):275-280. doi: 10.1097/FBP.0b013e328345f758
