TY - JOUR
T1 - Behavioral effects of MDMA ('ecstasy') on adult zebrafish
AU - Stewart, Adam
AU - Riehl, Russell
AU - Wong, Keith
AU - Green, Jeremy
AU - Cosgrove, Jessica
AU - Vollmer, Karoly
AU - Kyzar, Evan
AU - Hart, Peter
AU - Allain, Alexander
AU - Cachat, Jonathan
AU - Gaikwad, Siddharth
AU - Hook, Molly
AU - Rhymes, Kate
AU - Newman, Alan
AU - Utterback, Eli
AU - Chang, Katie
AU - Kalueff, Allan V.
PY - 2011/6
Y1 - 2011/6
N2 - 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.
AB - 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.
KW - 3,4-methylenedioxymethamphetamine
KW - anxiety
KW - locomotion
KW - novelty-based paradigms
KW - psychedelic hallucinogenic drugs
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=79955472632&partnerID=8YFLogxK
U2 - 10.1097/FBP.0b013e328345f758
DO - 10.1097/FBP.0b013e328345f758
M3 - Article
C2 - 21522057
AN - SCOPUS:79955472632
SN - 0955-8810
VL - 22
SP - 275
EP - 280
JO - Behavioural Pharmacology
JF - Behavioural Pharmacology
IS - 3
ER -