Behavioral and physiological effects of RDX on adult zebrafish

Larry R. Williams, Keith Wong, Adam Stewart, Christopher Suciu, Siddharth Gaikwad, Nadine Wu, John Dileo, Leah Grossman, Jonathan Cachat, Peter Hart, Allan V. Kalueff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

1,3,5-Trinitroperhydro-1,3,5-triazine (RDX) is a nitroamine explosive, with common toxic effects including seizures. Here, we explore the behavioral effects of acute RDX exposure in adult zebrafish Danio rerio, a rapidly developing model in neuroscience and neurotoxicology research. Overall, a 30-min exposure to RDX low dose of 0.1 mM evoked behavioral activation in zebrafish, while a higher dose of 1 mM markedly reduced exploration, increased freezing and evoked seizure-like responses (i.e., bouts of hyperactivity, spasms, and corkscrew swimming). Likewise, whole-body cortisol levels were also significantly elevated in fish exposed to 1 mM (but not 0.1 mM) RDX. In line with clinical and animal data, our study demonstrates the dose-dependent behavioral activation and pro-convulsant effects of RDX in zebrafish-based models.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalComparative Biochemistry and Physiology - C Toxicology and Pharmacology
Volume155
Issue number1
DOIs
Publication statusPublished - Jan 2012
Externally publishedYes

Keywords

  • Behavioral activation
  • Cortisol
  • Epilepsy
  • Pro-convulsant action
  • Seizures
  • Zebrafish

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