TY - JOUR
T1 - Application of proteomic tools in modern nanotechnological approaches towards effective management of neurodegenerative disorders
AU - Ali, Ashraf
AU - Sheikh, Ishfaq Ahmed
AU - Mirza, Zeenat
AU - Gan, Siew Hua
AU - Kamal, Mohammad Amjad
AU - Abuzenadah, Adel M.
AU - Damanhouri, Ghazi A.
AU - Ashraf, Ghulam Md
N1 - Publisher Copyright:
© 2015 Bentham Science Publishers.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Neurodegeneration is the progressive loss of structure or function of neurons leading to neuronal death, usually associated with ageing. Some of the common neurodegenerative disorders include Alzheimer's disease, Parkinson's disease, Creutzfeldt-Jakob disease, and Huntington's disease. Due to recent advancements in highthroughput technologies in various disciplines such as genomics, epigenomics, metabolomics and proteomics, there has been a great demand for detection of specific macromolecules such as hormones, drug residues, miRNA, DNA, antibodies, peptides, proteins, pathogens and xenobiotics at nano-level concentrations for in-depth understanding of disease mechanisms as well as for the development of new therapeutic strategies. The present review focuses on the management of agerelated neurodegenerative disorders using proteomics and nanotechnological approaches. In addition, this review also highlights the metabolism and disposition of nano-drugs and nano-enabled drug delivery in neurodegenerative disorders.
AB - Neurodegeneration is the progressive loss of structure or function of neurons leading to neuronal death, usually associated with ageing. Some of the common neurodegenerative disorders include Alzheimer's disease, Parkinson's disease, Creutzfeldt-Jakob disease, and Huntington's disease. Due to recent advancements in highthroughput technologies in various disciplines such as genomics, epigenomics, metabolomics and proteomics, there has been a great demand for detection of specific macromolecules such as hormones, drug residues, miRNA, DNA, antibodies, peptides, proteins, pathogens and xenobiotics at nano-level concentrations for in-depth understanding of disease mechanisms as well as for the development of new therapeutic strategies. The present review focuses on the management of agerelated neurodegenerative disorders using proteomics and nanotechnological approaches. In addition, this review also highlights the metabolism and disposition of nano-drugs and nano-enabled drug delivery in neurodegenerative disorders.
KW - Disposition
KW - Nano-applications
KW - Nano-drugs
KW - Nano-techniques
KW - Nanotechnology
KW - Neurological disorders
KW - Proteomics
UR - http://www.scopus.com/inward/record.url?scp=84945383896&partnerID=8YFLogxK
U2 - 10.2174/1389200216666141208153303
DO - 10.2174/1389200216666141208153303
M3 - Article
C2 - 25495738
AN - SCOPUS:84945383896
SN - 1389-2002
VL - 16
SP - 376
EP - 388
JO - Current Drug Metabolism
JF - Current Drug Metabolism
IS - 5
ER -