TY - JOUR
T1 - Anxiolytic-like effects of noribogaine in zebrafish
AU - Kalueff, Allan V.
AU - Kaluyeva, Aleksandra
AU - Mailet, Emeline L.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/7/14
Y1 - 2017/7/14
N2 - Noribogaine is the main psychoactive metabolite of the hallucinogenic drug ibogaine, and is a particularly interesting compound potentially useful to treat dependence and various psychiatric disorders. Here, we report the effects of noribogaine on anxiety and locomotion in zebrafish (Danio rerio), a new promising model organism in neurobehavioral and psychopharmacological research. Adult zebrafish were subjected to the 5 min novel tank test (NTT) following an acute, 20-min drug immersion in 1, 5 and 10 mg/L noribogaine. Overall, noribogaine produced robust anxiolytic-like behavior in zebrafish (increasing the time spent and transitions to the top half compartment and reducing freezing bouts) without overt effects on fish locomotion. Taken together, these results indicate that noribogaine modulates the components of the acute stress response related to emotionality and anxiety behaviors, implicating this drug as a potentially useful non-sedative anxiolytic agent.
AB - Noribogaine is the main psychoactive metabolite of the hallucinogenic drug ibogaine, and is a particularly interesting compound potentially useful to treat dependence and various psychiatric disorders. Here, we report the effects of noribogaine on anxiety and locomotion in zebrafish (Danio rerio), a new promising model organism in neurobehavioral and psychopharmacological research. Adult zebrafish were subjected to the 5 min novel tank test (NTT) following an acute, 20-min drug immersion in 1, 5 and 10 mg/L noribogaine. Overall, noribogaine produced robust anxiolytic-like behavior in zebrafish (increasing the time spent and transitions to the top half compartment and reducing freezing bouts) without overt effects on fish locomotion. Taken together, these results indicate that noribogaine modulates the components of the acute stress response related to emotionality and anxiety behaviors, implicating this drug as a potentially useful non-sedative anxiolytic agent.
KW - Anxiety
KW - Drug abuse
KW - Noribogaine
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85019834438&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2017.05.008
DO - 10.1016/j.bbr.2017.05.008
M3 - Article
C2 - 28479267
AN - SCOPUS:85019834438
SN - 0166-4328
VL - 330
SP - 63
EP - 67
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -