Abstract
The antibiotic benzylpenicillin was found to produce dose-dependent antiulcerogenic effects in rats when administered immediately before their exposure to acute stress (swimming for 1 h) that led to gastric mucosal ulceration. Such effects were not observed in rats given benzylpenicillin 48 h before stress exposure. The results of this study suggest that in acutely stressed animals benzylpenicillin may activate as yet unidentified mechanisms which afford protection to the gastric mucosa and which are not associated with the longer-lasting antimicrobial effects of this antibiotic.
| Original language | English |
|---|---|
| Pages (from-to) | 818-820 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 118 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 1994 |
| Externally published | Yes |
Keywords
- acute stress
- benzylpenicillin
- ulcerogenesis