TY - JOUR
T1 - Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice
AU - Kalueff, Allan V.
AU - Minasyan, Anna
AU - Tuohimaa, Pentti
PY - 2005/9/30
Y1 - 2005/9/30
N2 - Here, we study the role of a neurosteroid hormone Vitamin D in epilepsy. To examine this problem, we used 1,25-dihydroxyvitamin D, an active form of Vitamin D, injected subcutaneously to NMRI mice (33 μg/20 μl) 40 min prior to seizures induced by systemic injection of pentylenenetrazole (PTZ, 70 mg/kg). Overall, compared to the vehicle-treated control animals (n = 11 in each group), the Vitamin D-treated mice demonstrated reduced severity of PTZ-induced seizures (longer latency, shorter duration and lower mortality). In a separate experiment, we assessed the time-course of antiepileptic effects of 1,25-dihydroxyvitamin D. For this, we injected this compound (33 μg/20 μl) to NMRIx129S1 mice (n = 11) 40 min, 3, 6, 12 and 24 h prior to seizures, showing that antiepileptic effects were short-term, almost disappearing 3 h after administration. Our findings show that Vitamin D plays a direct anticonvulsant role in the brain and suggest that the Vitamin D endocrine system may represent a new target for the development of anticonvulsant drugs.
AB - Here, we study the role of a neurosteroid hormone Vitamin D in epilepsy. To examine this problem, we used 1,25-dihydroxyvitamin D, an active form of Vitamin D, injected subcutaneously to NMRI mice (33 μg/20 μl) 40 min prior to seizures induced by systemic injection of pentylenenetrazole (PTZ, 70 mg/kg). Overall, compared to the vehicle-treated control animals (n = 11 in each group), the Vitamin D-treated mice demonstrated reduced severity of PTZ-induced seizures (longer latency, shorter duration and lower mortality). In a separate experiment, we assessed the time-course of antiepileptic effects of 1,25-dihydroxyvitamin D. For this, we injected this compound (33 μg/20 μl) to NMRIx129S1 mice (n = 11) 40 min, 3, 6, 12 and 24 h prior to seizures, showing that antiepileptic effects were short-term, almost disappearing 3 h after administration. Our findings show that Vitamin D plays a direct anticonvulsant role in the brain and suggest that the Vitamin D endocrine system may represent a new target for the development of anticonvulsant drugs.
KW - 1,25-Dihydroxyvitamin D
KW - Chemically induced seizures
KW - Epilepsy
KW - Mice
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=24044468728&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2005.06.022
DO - 10.1016/j.brainresbull.2005.06.022
M3 - Article
C2 - 16140175
AN - SCOPUS:24044468728
SN - 0361-9230
VL - 67
SP - 156
EP - 160
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 1-2
ER -