Analyzing habituation responses to novelty in zebrafish (Danio rerio)

Keith Wong; Marco Elegante; Brett Bartels; Salem Elkhayat; David Tien; Sudipta Roy; Jason Goodspeed; Chris Suciu; Julia Tan; Chelsea Grimes; Amanda Chung; Michael Rosenberg; Siddharth Gaikwad; Ashley Denmark; Andrew Jackson; Ferdous Kadri; Kyung Min Chung; Adam Stewart; Tom Gilder; Esther Beeson; Ivan Zapolsky; Nadine Wu; Jonathan Cachat; Allan V. Kalueff

doi:10.1016/j.bbr.2009.12.023

Analyzing habituation responses to novelty in zebrafish (Danio rerio)

Keith Wong, Marco Elegante, Brett Bartels, Salem Elkhayat, David Tien, Sudipta Roy, Jason Goodspeed, Chris Suciu, Julia Tan, Chelsea Grimes, Amanda Chung, Michael Rosenberg, Siddharth Gaikwad, Ashley Denmark, Andrew Jackson, Ferdous Kadri, Kyung Min Chung, Adam Stewart, Tom Gilder, Esther BeesonIvan Zapolsky, Nadine Wu, Jonathan Cachat, Allan V. Kalueff^*

^*Corresponding author for this work

Tulane University

Research output: Contribution to journal › Article › peer-review

362 Citations (Scopus)

Abstract

Analysis of habituation is widely used to characterize animal cognitive phenotypes and their modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral research, their habituation responses have not been extensively investigated. Utilizing the novel tank test, we examine intra- and inter-session habituation and demonstrate robust habituation responses in adult zebrafish. Analyzing the intra-session habituation to novelty further, we also show that selected anxiogenic drugs (caffeine, pentylenetetrazole), as well as stress-inducing alarm pheromone, attenuated zebrafish habituation. Some acute anxiolytic agents, such as morphine and ethanol, while predictably reducing zebrafish anxiety, had no effects on habituation. Chronic ethanol and fluoxetine treatments improved intra-session habituation in zebrafish. In general, our study parallels literature on rodent habituation responses to novelty, and reconfirms zebrafish as a promising model for cognitive neurobehavioral research.

Original language	English
Pages (from-to)	450-457
Number of pages	8
Journal	Behavioural Brain Research
Volume	208
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2009.12.023
Publication status	Published - 2 Apr 2010
Externally published	Yes

Keywords

Anxiety
Cognition and learning
Drug effects
Habituation to novelty
Spatial working memory
Zebrafish

Access to Document

10.1016/j.bbr.2009.12.023

Cite this

Wong, K., Elegante, M., Bartels, B., Elkhayat, S., Tien, D., Roy, S., Goodspeed, J., Suciu, C., Tan, J., Grimes, C., Chung, A., Rosenberg, M., Gaikwad, S., Denmark, A., Jackson, A., Kadri, F., Chung, K. M., Stewart, A., Gilder, T., ... Kalueff, A. V. (2010). Analyzing habituation responses to novelty in zebrafish (Danio rerio). Behavioural Brain Research, 208(2), 450-457. https://doi.org/10.1016/j.bbr.2009.12.023

@article{4145fa997ca247e4a691ff2830531352,

title = "Analyzing habituation responses to novelty in zebrafish (Danio rerio)",

abstract = "Analysis of habituation is widely used to characterize animal cognitive phenotypes and their modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral research, their habituation responses have not been extensively investigated. Utilizing the novel tank test, we examine intra- and inter-session habituation and demonstrate robust habituation responses in adult zebrafish. Analyzing the intra-session habituation to novelty further, we also show that selected anxiogenic drugs (caffeine, pentylenetetrazole), as well as stress-inducing alarm pheromone, attenuated zebrafish habituation. Some acute anxiolytic agents, such as morphine and ethanol, while predictably reducing zebrafish anxiety, had no effects on habituation. Chronic ethanol and fluoxetine treatments improved intra-session habituation in zebrafish. In general, our study parallels literature on rodent habituation responses to novelty, and reconfirms zebrafish as a promising model for cognitive neurobehavioral research.",

keywords = "Anxiety, Cognition and learning, Drug effects, Habituation to novelty, Spatial working memory, Zebrafish",

author = "Keith Wong and Marco Elegante and Brett Bartels and Salem Elkhayat and David Tien and Sudipta Roy and Jason Goodspeed and Chris Suciu and Julia Tan and Chelsea Grimes and Amanda Chung and Michael Rosenberg and Siddharth Gaikwad and Ashley Denmark and Andrew Jackson and Ferdous Kadri and Chung, {Kyung Min} and Adam Stewart and Tom Gilder and Esther Beeson and Ivan Zapolsky and Nadine Wu and Jonathan Cachat and Kalueff, {Allan V.}",

year = "2010",

month = apr,

day = "2",

doi = "10.1016/j.bbr.2009.12.023",

language = "English",

volume = "208",

pages = "450--457",

journal = "Behavioural Brain Research",

issn = "0166-4328",

number = "2",

}

Wong, K, Elegante, M, Bartels, B, Elkhayat, S, Tien, D, Roy, S, Goodspeed, J, Suciu, C, Tan, J, Grimes, C, Chung, A, Rosenberg, M, Gaikwad, S, Denmark, A, Jackson, A, Kadri, F, Chung, KM, Stewart, A, Gilder, T, Beeson, E, Zapolsky, I, Wu, N, Cachat, J & Kalueff, AV 2010, 'Analyzing habituation responses to novelty in zebrafish (Danio rerio)', Behavioural Brain Research, vol. 208, no. 2, pp. 450-457. https://doi.org/10.1016/j.bbr.2009.12.023

TY - JOUR

T1 - Analyzing habituation responses to novelty in zebrafish (Danio rerio)

AU - Wong, Keith

AU - Elegante, Marco

AU - Bartels, Brett

AU - Elkhayat, Salem

AU - Tien, David

AU - Roy, Sudipta

AU - Goodspeed, Jason

AU - Suciu, Chris

AU - Tan, Julia

AU - Grimes, Chelsea

AU - Chung, Amanda

AU - Rosenberg, Michael

AU - Gaikwad, Siddharth

AU - Denmark, Ashley

AU - Jackson, Andrew

AU - Kadri, Ferdous

AU - Chung, Kyung Min

AU - Stewart, Adam

AU - Gilder, Tom

AU - Beeson, Esther

AU - Zapolsky, Ivan

AU - Wu, Nadine

AU - Cachat, Jonathan

AU - Kalueff, Allan V.

PY - 2010/4/2

Y1 - 2010/4/2

N2 - Analysis of habituation is widely used to characterize animal cognitive phenotypes and their modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral research, their habituation responses have not been extensively investigated. Utilizing the novel tank test, we examine intra- and inter-session habituation and demonstrate robust habituation responses in adult zebrafish. Analyzing the intra-session habituation to novelty further, we also show that selected anxiogenic drugs (caffeine, pentylenetetrazole), as well as stress-inducing alarm pheromone, attenuated zebrafish habituation. Some acute anxiolytic agents, such as morphine and ethanol, while predictably reducing zebrafish anxiety, had no effects on habituation. Chronic ethanol and fluoxetine treatments improved intra-session habituation in zebrafish. In general, our study parallels literature on rodent habituation responses to novelty, and reconfirms zebrafish as a promising model for cognitive neurobehavioral research.

AB - Analysis of habituation is widely used to characterize animal cognitive phenotypes and their modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral research, their habituation responses have not been extensively investigated. Utilizing the novel tank test, we examine intra- and inter-session habituation and demonstrate robust habituation responses in adult zebrafish. Analyzing the intra-session habituation to novelty further, we also show that selected anxiogenic drugs (caffeine, pentylenetetrazole), as well as stress-inducing alarm pheromone, attenuated zebrafish habituation. Some acute anxiolytic agents, such as morphine and ethanol, while predictably reducing zebrafish anxiety, had no effects on habituation. Chronic ethanol and fluoxetine treatments improved intra-session habituation in zebrafish. In general, our study parallels literature on rodent habituation responses to novelty, and reconfirms zebrafish as a promising model for cognitive neurobehavioral research.

KW - Anxiety

KW - Cognition and learning

KW - Drug effects

KW - Habituation to novelty

KW - Spatial working memory

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=77249127921&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2009.12.023

DO - 10.1016/j.bbr.2009.12.023

M3 - Article

C2 - 20035794

AN - SCOPUS:77249127921

SN - 0166-4328

VL - 208

SP - 450

EP - 457

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

ER -

Analyzing habituation responses to novelty in zebrafish (Danio rerio)

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this