Abstract
Commonly observed in laboratory rodents, abnormal repetitive behaviors are an important domain for biomedical research. The neurological abnormalities associated with some behavioral perseverations and stereotypies in animals are similar to human brain disorders (for example, trichotillomania and obsessive-compulsive spectrum disorders), suggesting that micro-behavioral analysis of these phenotypes may benefit research in biological psychiatry. Additionally, expression of such phenotypes is highly sensitive to genetic manipulations, as well as environmental, social, husbandry, and other stressors. In this chapter we will discuss some specific rodent behavioral perseverations and stereotypies, their environmental modifiers, as well as potential translational value of these animal phenotypes.
| Original language | English |
|---|---|
| Title of host publication | Translational Neuroscience in Animal Research |
| Subtitle of host publication | Advancement, Challenges, and Research Ethics |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 71-82 |
| Number of pages | 12 |
| ISBN (Print) | 9781608761852 |
| Publication status | Published - Feb 2011 |
| Externally published | Yes |
Keywords
- Abnormal repetitive behaviors
- Animal models
- Barbering
- Behavioral perseverations
- Genetic factors
- Obsessive-compulsive disorders
- Stereotypies
- Stress.