Advances in dissolving microneedles-based drug delivery system for treating dermatological diseases

Gang Chen, Jiaying Li, Qinglei Bu, Yujiang Li, Ziyang Chen, Jie Sun*, Yongyong Li*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Different from common methods for dermatological diseases treatment, dissolving MNs (DMNs) loaded with active pharmaceutical ingredients (APIs) have been identified as a promising approach for the delivery of drugs and vaccines, which revolutionize drug delivery with controlled release rates at target topical lesions. Hence, drugs can be designed and delivered to meet individual needs through controlling the dose and ingredients. The objectives of this study are to collate, analyze, categorize, and summarize published articles and papers pertaining to DMNs and its applications on dermatological diseases, as well as to provide a critical insight into the direction of its future development. From the available references, DMNs should be designed with sufficient mechanical strength, needle length and dissolvability for specific disease treatment. The available machine learning applications potentially applicable to optimize DMNs design and evaluate its efficacy are presented. Essentially, DMNs provides an effective solution for skin disease treatment and customized drug release for clinical applications.

Original languageEnglish
Article number106785
JournalJournal of Drug Delivery Science and Technology
Volume107
DOIs
Publication statusPublished - May 2025

Keywords

  • Dermatological diseases
  • Dissolving microneedles
  • Transdermal drug delivery system

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