Active methylene phosphinic peptides: A new diversification approach

Magdalini Matziari; Magdalini Nasopoulou; Athanasios Yiotakis

doi:10.1021/ol060575m

Active methylene phosphinic peptides: A new diversification approach

Magdalini Matziari, Magdalini Nasopoulou, Athanasios Yiotakis^*

^*Corresponding author for this work

National and Kapodistrian University of Athens

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Simple, rapid, and efficient methods for P₁′ diversification of phosphinic peptides have been developed, employing alkylation and Knoevenagel-type condensation reactions with active methylene phosphinic scaffolds, thus leading to a wide variety of diversified phosphinic and dehydrophosphinic peptides.

Original language	English
Pages (from-to)	2317-2319
Number of pages	3
Journal	Organic Letters
Volume	8
Issue number	11
DOIs	https://doi.org/10.1021/ol060575m
Publication status	Published - 25 May 2006
Externally published	Yes

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title = "Active methylene phosphinic peptides: A new diversification approach",

abstract = "Simple, rapid, and efficient methods for P1′ diversification of phosphinic peptides have been developed, employing alkylation and Knoevenagel-type condensation reactions with active methylene phosphinic scaffolds, thus leading to a wide variety of diversified phosphinic and dehydrophosphinic peptides.",

author = "Magdalini Matziari and Magdalini Nasopoulou and Athanasios Yiotakis",

year = "2006",

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AU - Matziari, Magdalini

AU - Nasopoulou, Magdalini

AU - Yiotakis, Athanasios

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N2 - Simple, rapid, and efficient methods for P1′ diversification of phosphinic peptides have been developed, employing alkylation and Knoevenagel-type condensation reactions with active methylene phosphinic scaffolds, thus leading to a wide variety of diversified phosphinic and dehydrophosphinic peptides.

AB - Simple, rapid, and efficient methods for P1′ diversification of phosphinic peptides have been developed, employing alkylation and Knoevenagel-type condensation reactions with active methylene phosphinic scaffolds, thus leading to a wide variety of diversified phosphinic and dehydrophosphinic peptides.

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U2 - 10.1021/ol060575m

DO - 10.1021/ol060575m

M3 - Article

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SP - 2317

EP - 2319

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

Active methylene phosphinic peptides: A new diversification approach

Abstract

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