TY - JOUR
T1 - A novel screen-printed electrode modified by graphene nanocomposite for detecting clozapine
AU - Beitollahi, Hadi
AU - Tajik, Somayeh
AU - Aflatoonian, Mohammad Reza
AU - Nejad, Fariba Garkani
AU - Zhang, Kaiqiang
AU - Asl, Mehdi Shahedi
AU - Van Le, Quyet
AU - Cha, Joo Hwan
AU - Shokouhimehr, Mohammadreza
AU - Peng, Wanxi
N1 - Publisher Copyright:
© 2020 The Authors.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Present study aims to use Go/Fe3O4/SiO2 nanocomposite modified screen printed electrode for electrochemical determination of clozapine. To that end, scanning electron microscopy (SEM) technique was used to study the surface morphology of the Go/Fe3O4/SiO2 nanocomposite. The findings of the study showed that modified electrode has an excellent electrocatalytic performance toward oxidation of clozapine. A linear increase in differential pulse voltammetric peaks current of clozapine was observed with their concentrations in the range of 0.1-700.0 μM. The detection limit obtained for clozapine was 0.03 μM. Some advantages of using proposed sensor, among the others, were fast response time, high sensitivity, signal stability, low cost, ease of preparation and the lack of need for using any specific electron-transfer mediator or specific reagent. Accordingly, modified electrode can be used without any need for separation or pretreatment steps to detect clozapine in real samples.
AB - Present study aims to use Go/Fe3O4/SiO2 nanocomposite modified screen printed electrode for electrochemical determination of clozapine. To that end, scanning electron microscopy (SEM) technique was used to study the surface morphology of the Go/Fe3O4/SiO2 nanocomposite. The findings of the study showed that modified electrode has an excellent electrocatalytic performance toward oxidation of clozapine. A linear increase in differential pulse voltammetric peaks current of clozapine was observed with their concentrations in the range of 0.1-700.0 μM. The detection limit obtained for clozapine was 0.03 μM. Some advantages of using proposed sensor, among the others, were fast response time, high sensitivity, signal stability, low cost, ease of preparation and the lack of need for using any specific electron-transfer mediator or specific reagent. Accordingly, modified electrode can be used without any need for separation or pretreatment steps to detect clozapine in real samples.
KW - Clozapine
KW - Go/FeO/SiOnanocomposite
KW - Modified electrode
KW - Screen printed electrode
KW - Voltammetry
UR - http://www.scopus.com/inward/record.url?scp=85091492510&partnerID=8YFLogxK
U2 - 10.20964/2020.09.22
DO - 10.20964/2020.09.22
M3 - Article
AN - SCOPUS:85091492510
SN - 1452-3981
VL - 15
SP - 9271
EP - 9281
JO - International Journal of Electrochemical Science
JF - International Journal of Electrochemical Science
IS - 9
ER -