@inproceedings{06bc478ad2504212965cabb2cea6b1c6,
title = "A Meta-analysis: Evaluating the Effect of METTL3/METTL14 on m6A Level Based on Knockdown Samples",
abstract = "N6-methyladenosine (m6A) is a dynamic modification regulated by the m6A enzymes prevalent on mRNA. The Mettl3 and mettl14 are two subunits of methyltransferase. Different studies have shown that knockout of the METL3 and MTEL14 genes has the potential to change methylation levels. We have therefore undertaken a meta-analysis study to assess the quality and quantity of available evidence. The focus of the research would on the effects of mRNA methylation level after the depletion of METTL3 or METTL14. R package {"}Metafor{"}was applied to output the model of random effect, the regarding risk ratios (RRs), and the 95% confidence intervals (CIs). Owing to the high heterogeneity of the overall data (I2>99%), some samples were selected and excluded to an acceptable level. Three published trials for METTL3 (Q = 12.85, I2 = 37.8%) and two for METTL4 (Q = 45.48, I2 = 82.9%) were qualified to review and analyze. Consequently, we successfully proved the correlation between the knockdown of METTL3/METTL14 and modification of methylation level.",
keywords = "Meta-analysis, Methylation level, Writers, m6A",
author = "Yuxin Zhang and Yuxuan Wu and Di Zhen and Kunqi Chen and Jia Meng",
note = "Publisher Copyright: {\textcopyright} 2021 ACM.; 5th International Conference on Biological Information and Biomedical Engineering, BIBE 2021 ; Conference date: 20-07-2021 Through 21-07-2021",
year = "2021",
month = jul,
day = "20",
doi = "10.1145/3469678.3469715",
language = "English",
series = "ACM International Conference Proceeding Series",
publisher = "Association for Computing Machinery",
editor = "Bin Chen",
booktitle = "Proceedings of the 5th International Conference on Biological Information and Biomedical Engineering, BIBE 2021",
}