A mag dot-nanoconveyor assay detects and isolates molecular biomarkers

Kalpesh D. Mahajan; Gregory B. Vieira; Gang Ruan; Brandon L. Miller; Maryam B. Lustberg; Jeffrey J. Chalmers; Ratnasingham Sooryakumar; Jessica O. Winter

A mag dot-nanoconveyor assay detects and isolates molecular biomarkers

Kalpesh D. Mahajan^*, Gregory B. Vieira, Gang Ruan, Brandon L. Miller, Maryam B. Lustberg, Jeffrey J. Chalmers, Ratnasingham Sooryakumar, Jessica O. Winter

^*Corresponding author for this work

Ohio State University

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

A simple biomarker is the concentration of the small molecule glucose. Newer biomarkers like pharmacogenetic biomarkers, have the potential to identify which patients may benefit most from a therapy with the least amount of toxicity. Appropriate biomarker selection is critical for new drug development, since only some patients may benefit from a targeted therapy. Improved technology for the detection and separation of biomarkers is needed to identify and validate predictive biomarkers. Accurate detection of soluble biomarkers is crucial for eliminating false positives and false negatives in medical diagnostics. Cell surface biomarkers present different challenges. Cell surface biomarker assays must typically isolate the cell in order to detect its inherent biomarkers. One possible way to address these issues is the use of nanotechnology based molecular detection schemes.

Original language	English
Pages (from-to)	41-46+51
Journal	Chemical Engineering Progress
Volume	108
Issue number	12
Publication status	Published - Dec 2012
Externally published	Yes

Cite this

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title = "A mag dot-nanoconveyor assay detects and isolates molecular biomarkers",

abstract = "A simple biomarker is the concentration of the small molecule glucose. Newer biomarkers like pharmacogenetic biomarkers, have the potential to identify which patients may benefit most from a therapy with the least amount of toxicity. Appropriate biomarker selection is critical for new drug development, since only some patients may benefit from a targeted therapy. Improved technology for the detection and separation of biomarkers is needed to identify and validate predictive biomarkers. Accurate detection of soluble biomarkers is crucial for eliminating false positives and false negatives in medical diagnostics. Cell surface biomarkers present different challenges. Cell surface biomarker assays must typically isolate the cell in order to detect its inherent biomarkers. One possible way to address these issues is the use of nanotechnology based molecular detection schemes.",

author = "Mahajan, {Kalpesh D.} and Vieira, {Gregory B.} and Gang Ruan and Miller, {Brandon L.} and Lustberg, {Maryam B.} and Chalmers, {Jeffrey J.} and Ratnasingham Sooryakumar and Winter, {Jessica O.}",

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AU - Vieira, Gregory B.

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AU - Miller, Brandon L.

AU - Lustberg, Maryam B.

AU - Chalmers, Jeffrey J.

AU - Sooryakumar, Ratnasingham

AU - Winter, Jessica O.

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AB - A simple biomarker is the concentration of the small molecule glucose. Newer biomarkers like pharmacogenetic biomarkers, have the potential to identify which patients may benefit most from a therapy with the least amount of toxicity. Appropriate biomarker selection is critical for new drug development, since only some patients may benefit from a targeted therapy. Improved technology for the detection and separation of biomarkers is needed to identify and validate predictive biomarkers. Accurate detection of soluble biomarkers is crucial for eliminating false positives and false negatives in medical diagnostics. Cell surface biomarkers present different challenges. Cell surface biomarker assays must typically isolate the cell in order to detect its inherent biomarkers. One possible way to address these issues is the use of nanotechnology based molecular detection schemes.

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JO - Chemical Engineering Progress

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A mag dot-nanoconveyor assay detects and isolates molecular biomarkers

Abstract

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