A linear classification approach to model the early cellular responses induced by drugs

Dechang Xu; Zhiying Liang; Dayou Cheng; Cuihong Dai; Aiju Hou; Liqiang Pan; Jianzhong Li

doi:10.1109/BIBM.2014.6999397

A linear classification approach to model the early cellular responses induced by drugs

Dechang Xu, Zhiying Liang, Dayou Cheng, Cuihong Dai, Aiju Hou, Liqiang Pan, Jianzhong Li

Harbin Institute of Technology

Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review

Abstract

To quantitatively discover the protein sub-cellular translocation pattern which responds to drugs' treatment doses is a challenge for medical applications with bio-imaging and machine learning on the Single-channel Protein Sub-cellular Location Fluorescence Images without segmentation. This paper suggested a Linear Classification Approach to model the Early Cellular Responses Induced by Drugs. Based on published image-set data, our methods' Accuracy, Precision, Recall and F-Score will be more than 0.70, 0.71, 0.65 and 0.71 respectively.

Original language	English
Title of host publication	Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Editors	Huiru Zheng, Xiaohua Tony Hu, Daniel Berrar, Yadong Wang, Werner Dubitzky, Jin-Kao Hao, Kwang-Hyun Cho, David Gilbert
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	27-29
Number of pages	3
ISBN (Electronic)	9781479956692
DOIs	https://doi.org/10.1109/BIBM.2014.6999397
Publication status	Published - 29 Dec 2014
Externally published	Yes
Event	2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 - Belfast, United Kingdom Duration: 2 Nov 2014 → 5 Nov 2014

Publication series

Name	Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

Conference

Conference	2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Country/Territory	United Kingdom
City	Belfast
Period	2/11/14 → 5/11/14

Keywords

linear classification
protein sub-cellular translocation
SIFT-SVM

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10.1109/BIBM.2014.6999397

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Xu, D., Liang, Z., Cheng, D., Dai, C., Hou, A., Pan, L., & Li, J. (2014). A linear classification approach to model the early cellular responses induced by drugs. In H. Zheng, X. T. Hu, D. Berrar, Y. Wang, W. Dubitzky, J.-K. Hao, K.-H. Cho, & D. Gilbert (Eds.), Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 (pp. 27-29). Article 6999397 (Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2014.6999397

Xu, Dechang ; Liang, Zhiying ; Cheng, Dayou et al. / A linear classification approach to model the early cellular responses induced by drugs. Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014. editor / Huiru Zheng ; Xiaohua Tony Hu ; Daniel Berrar ; Yadong Wang ; Werner Dubitzky ; Jin-Kao Hao ; Kwang-Hyun Cho ; David Gilbert. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 27-29 (Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014).

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abstract = "To quantitatively discover the protein sub-cellular translocation pattern which responds to drugs' treatment doses is a challenge for medical applications with bio-imaging and machine learning on the Single-channel Protein Sub-cellular Location Fluorescence Images without segmentation. This paper suggested a Linear Classification Approach to model the Early Cellular Responses Induced by Drugs. Based on published image-set data, our methods' Accuracy, Precision, Recall and F-Score will be more than 0.70, 0.71, 0.65 and 0.71 respectively.",

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author = "Dechang Xu and Zhiying Liang and Dayou Cheng and Cuihong Dai and Aiju Hou and Liqiang Pan and Jianzhong Li",

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doi = "10.1109/BIBM.2014.6999397",

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Xu, D, Liang, Z, Cheng, D, Dai, C, Hou, A, Pan, L & Li, J 2014, A linear classification approach to model the early cellular responses induced by drugs. in H Zheng, XT Hu, D Berrar, Y Wang, W Dubitzky, J-K Hao, K-H Cho & D Gilbert (eds), Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014., 6999397, Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014, Institute of Electrical and Electronics Engineers Inc., pp. 27-29, 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014, Belfast, United Kingdom, 2/11/14. https://doi.org/10.1109/BIBM.2014.6999397

A linear classification approach to model the early cellular responses induced by drugs. / Xu, Dechang; Liang, Zhiying; Cheng, Dayou et al.
Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014. ed. / Huiru Zheng; Xiaohua Tony Hu; Daniel Berrar; Yadong Wang; Werner Dubitzky; Jin-Kao Hao; Kwang-Hyun Cho; David Gilbert. Institute of Electrical and Electronics Engineers Inc., 2014. p. 27-29 6999397 (Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014).

Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review

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AB - To quantitatively discover the protein sub-cellular translocation pattern which responds to drugs' treatment doses is a challenge for medical applications with bio-imaging and machine learning on the Single-channel Protein Sub-cellular Location Fluorescence Images without segmentation. This paper suggested a Linear Classification Approach to model the Early Cellular Responses Induced by Drugs. Based on published image-set data, our methods' Accuracy, Precision, Recall and F-Score will be more than 0.70, 0.71, 0.65 and 0.71 respectively.

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Xu D, Liang Z, Cheng D, Dai C, Hou A, Pan L et al. A linear classification approach to model the early cellular responses induced by drugs. In Zheng H, Hu XT, Berrar D, Wang Y, Dubitzky W, Hao JK, Cho KH, Gilbert D, editors, Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 27-29. 6999397. (Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014). doi: 10.1109/BIBM.2014.6999397

A linear classification approach to model the early cellular responses induced by drugs

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