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Abstract
A new method was developed for the synthesis of Linezolid from commercially available (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one. Linezolid is an antibiotic belongs to the family of oxazolidinones, it is successfully synthesized through a new method which include Buchwald-Hartwig amination reaction and Gabriel amine synthesis as the key steps. The synthetic route is easy to perform and with high yield. This new method provides a huge possibility for the synthesis of new linezolid derivatives that may possibly tackle the problem of bacteria resistance to oxazolidinones.
Original language | English |
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Article number | 154050 |
Journal | Tetrahedron Letters |
Volume | 105 |
DOIs | |
Publication status | Published - Aug 2022 |
Keywords
- Antibiotic
- BMGQMLDNAYSSOT-ZNZWXRCUSA-N
- Buchwald-Hartwig reaction
- Gram-positive bacteria
- Linezolid
- NKYJEIUMGFRATE-YGBVEIAUSA-N
- OWGUMPFGBPKPRD-CNXQYKSLSA-N
- Synthesis of new oxazolidinones
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Dive into the research topics of 'A convenient synthesis of linezolid through Buchwald-Hartwig amination'. Together they form a unique fingerprint.Activities
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Review of Linezolid, mechanism of action, applications, and synthesis methods. (FYP project 2022)
Keyin Wang (Participant) & Qian Zhang (Participant)
Sept 2021 → May 2022Activity: Other