A convenient synthesis of linezolid through Buchwald-Hartwig amination

Keyin Wang, Yinzhe Chen, Siyuan Wang, Qian Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A new method was developed for the synthesis of Linezolid from commercially available (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one. Linezolid is an antibiotic belongs to the family of oxazolidinones, it is successfully synthesized through a new method which include Buchwald-Hartwig amination reaction and Gabriel amine synthesis as the key steps. The synthetic route is easy to perform and with high yield. This new method provides a huge possibility for the synthesis of new linezolid derivatives that may possibly tackle the problem of bacteria resistance to oxazolidinones.

Original languageEnglish
Article number154050
JournalTetrahedron Letters
Volume105
DOIs
Publication statusPublished - Aug 2022

Keywords

  • Antibiotic
  • BMGQMLDNAYSSOT-ZNZWXRCUSA-N
  • Buchwald-Hartwig reaction
  • Gram-positive bacteria
  • Linezolid
  • NKYJEIUMGFRATE-YGBVEIAUSA-N
  • OWGUMPFGBPKPRD-CNXQYKSLSA-N
  • Synthesis of new oxazolidinones

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