Projects per year
Personal profile
Personal profile
Weiwei Dai received his B.S. in Biotechnology from Northwest University, Xi’an (2008), M.Sc. in Fish Nutrition from Ocean University of China, Qingdao (2011), and Ph.D. in Institut National de la Recherche Agronomique (INRA), France (2016). During 2016 and 2023, Dr. Dai continued his academic career in United States as a postdoctoral fellow at The Pennsylvania State University (2016-2018) and a Post-Doctoral Associate at Rutgers University (2018-2023). Dr. Dai joined the Department of Biological Sciences at XJTLU as an assistant professor in June, 2023, and serves as the Co-Director of Suzhou Municipal Key Lab for Metabolic Syndrome Drug Research since January, 2024. Dr. Dai's research has been mainly focused on studying nutrition and metabolism in liver and metabolic diseases including obesity and liver cancer. Currently, he is focusing on studying cancer metabolism, especially amino acid/nitrogen metabolism in liver cancer, as well as epigenetic regulation on metabolic enzymes in liver tumor microenvironments. Dr. Dai has published 17 peer-reviewed papers, including 8 first-author SCI research articles, such as J Clin Invest (IF=19.5), The FASEB Journal, JMCB, BBA Mol Basis Dis., and 2 second-author articles; as well as 2 first-author patents for invention. Dr. Dai is funded by the National Natural Science Foundation of China general project (2025-2028) as the Principal investigator. Dr. Dai also actively serves in the academic community as a member of Chinese Society for Cell Biology and The Chinese Society of Biochemistry and Molecular Biology, as well as journal reviewers for Journal of Molecular Cell Biology (IF=8.19), Clinical Science (IF=5.22), Frontiers in Nutrition (IF=5), and Bioscience Reports.
代伟伟本科毕业于西北大学生物技术专业(2008);硕士毕业于中国海洋大学(2011),师从麦康森院士和艾庆辉教授(“国家杰青”、“长江学者”);博士毕业于法国国家农业科学研究院(INRA,2016)。2016-2023年期间先后在美国宾夕法尼亚州立大学和罗格斯大学从事博士后研究。代博士2023年6月加入西交利物浦大学生物科学系。过去数十年代博士一直从事肝脏营养和代谢研究,目前的主要研究方向为肿瘤代谢与氨基酸/氮代谢。近几年以第一作者在J Clin Invest (IF=19.5),The FASEB Journal,JMCB,BBA Mol Basis Dis.等经典SCI杂志发表科研文章11篇;共同作者文章7篇;第一发明人发明专利2项; 主持国家自然科学基金面上项目一项(2025-2028)。中国细胞生物学学会、中国生物物理学会、中国生物化学与分子生物学、中国营养学会和苏州市生物学会会员。同时担任Journal of Molecular Cell Biology, Clinical Science、Frontiers in Nutrition, Bioscience Reports 和Aquaculture等杂志的审稿人。
Dr. Dai's recent research talk on CST webinars can be accessed below:https://learn.cellsignal.cn/cn-online-seminar 代博士近期在CST博士云讲座的报告“谷氨酰胺合成酶通过调节氮代谢和抑制mTORC1活性限制肝肿瘤生长”可以通过以下链接观看:https://learn.cellsignal.cn/cn-online-seminar
Dr. Dai Webpage: https://connect.xjtlu.edu.cn/user/weiwei-dai
Dai Lab: https://connect.xjtlu.edu.cn/group/dai-lab-bio-department
Suzhou Key Lab: https://connect.xjtlu.edu.cn/group/suzhou-key-lab-in-metabolic-di
DAI Lab available PhD positions with scholarship can be found below:
Research interests
Nitrogen metabolism in physiology and metabolic diseases including obesity and liver cancer
Nutritional regulation of mTOR activation (mTORC1 and mTORC2)
Cancer metabolism: Urea cycle dysregulation- and ammonia accumulation-induced effects on cancer cells and immune cells
Dietary regulation and intervention on animal growth and tumor progression
Epigenetic regulation of metabolic enzymes
Hepatic Nitrogen Metabolism Reprogramming
Experience
Director, Suzhou Municipal Key Lab for Metabolic Syndrome Drug Research - 2024/05 to Present
Adjunct Associate Researcher (副研究员), Department of Biological Sciences, Xian Jiaotong-Liverpool University, China - 2024/05 to Present
Assistant Professor (助理教授), Department of Biological Sciences, Xian Jiaotong-Liverpool University, China - 2023/06 to Present
Post-Doctoral Researcher, School of Basic Medical Sciences, Fudan University, China - 2021 to 2023
Post-Doctoral Associate, Department of Chemical Biology, Rutgers University, New Jersey, USA - 2018 to 2020
Postdoctoral Fellow, Cell and Molecular Physiology, Penn State University College of Medicine, Hershey, PA, USA - 2016 to 2018
Teaching
Research Methods in Biotechnology – BIO401 (Module Leader / Coordinator, master module)
Key Skills for Life Scientists – BIO006 (Module Leader / Coordinator)
The Biology of Microbes – BIO106
BIO303 Final Year Project (Supervisor)
BIO406/407 Master Project (Supervisor)
Awards and honours
“Super Post-Doctorl Fellow” (Fudan, University) 2021-2023
CSC Scholarship (China Scholarship Council) 2011-2015
“Government-supported graduate student” 2008-2011
“Academic Star” of Fisheries College (3nd place, OUC) 2008-2009
Northwest University Scholarship (3 times) 2004-2007
“Best Minister” (University website, Journalist Department) 2006-2007
“Best Journalist” (University website) 2005-06
“Excellent Cadre” (class president) 2005-2006
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Related documents
Education/Academic qualification
Ph.D. , Institut National de la Recherche Agronomique (INRA), France - 2016
M.Sc. , Ocean University of China (OUC), Qingdao, China -2011
B.Sc. , Northwest University (NWU), Xi’an, China - 2008
Keywords
- QH301 Biology
- metabolism
- nutrition
- cancer
- mTOR
- amino acid
Person Types
- Staff
Fingerprint
Collaborations and top research areas from the last five years
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Multimodal Biomedical Data: Harnessing the Unlabeled Data to Enhance the Biomedical Interpretable Learning
Wang, S., Tang, M., Dai, W., Moraros, J., Meng, J., Zhang, Y. & Li, C.
1/09/24 → 31/08/27
Project: Governmental Research Project
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RDF: The mechanism of urea cycle suppression-induced ammonia accumulation promotes liver cancer progression via calcium-dependent manner
1/01/24 → 31/12/26
Project: Internal Research Project
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NSFC General Program: The mechanism of ammonia accumulation promotes liver cancer progression via calcium channel-mTORC2-SREBP1-lipogenesis dependent manner
Dai, W., Hamada, K., Elkord, E. & Cheng, K.
1/01/25 → 31/12/28
Project: Governmental Research Project
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The mechanism of ammonia accumulation promotes liver cancer progression via calcium channel-mTORC2-SREBP1-lipogenesis dependent manner
Dai, W., Wang, S., Chen, G., Elkord, E., Hamada, K., Cheng, K., Xu, J., Huang, S., Yang, C., Ma, J. & Bin, U.
1/01/25 → 31/12/28
Project: Governmental Research Project
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Novel roles of ammonia in physiology and cancer: Novel roles of ammonia in physiology and cancer
Chen, G., Wang, C. & Dai, W., 14 Jul 2024, (Submitted) In: Journal of Molecular Cell Biology. JMCB-2024-0254.Research output: Contribution to journal › Review article › peer-review
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Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance
Zhao, Z., Chen, Q., Xiang, X., Dai, W., Xu, W., Mai, K. & Ai, Q., 18 Oct 2024, In: Journal of Cell Biology. 223, 12, e202309090.Research output: Contribution to journal › Article › peer-review
File17 Downloads (Pure) -
Glutamine synthetase: a tumor suppressor in hepatocellular carcinoma?
Dai, W., 1 Jun 2023, In: Journal of Molecular Cell Biology. 15, 1, 10.1093/jmcb/mjad007.Research output: Contribution to journal › Article › peer-review
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Melittin inhibits tumor cell migration and enhances cisplatin sensitivity by suppressing IL-17 signaling pathway gene LCN2 in castration-resistant prostate cancer
Yan, R., Dai, W., Mao, Y., Yu, G., Li, W., Shu, M. & Xu, B., Nov 2023, In: Prostate. 83, 15, p. 1430-1445 16 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1
Dai, W., 18 Oct 2022, In: Journal of Clinical Investigation. 132, 24, 24 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus)
Activities
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Investigating the functional characteristics of SLC25A13 in Hepatocellular carcinoma progression and its underlying mechanisms
Weiwei Dai (Co-supervisor) & John Moraros (Supervisor)
1 Sept 2024 → 31 Aug 2027Activity: Supervision › PhD Supervision
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XJTLU UG Student Summer Research Mobility Program with Taylors’ University
Weiwei Dai (Organiser)
4 Aug 2024 → 29 Aug 2024Activity: Participating in or organising an event › Organising an event e.g. a conference, workshop, …
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The 2nd Immunometabolism Frontier Forum
Weiwei Dai (Participant)
3 Aug 2024 → 4 Aug 2024Activity: Participating in or organising an event › Participating in an event e.g. a conference, workshop, …
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中国细胞生物学学会第十五期细胞黄浦(WLLA)研修班
Weiwei Dai (Participant)
20 Jul 2024 → 23 Jul 2024Activity: Participating in or organising an event › Participating in an event e.g. a conference, workshop, …