Projects per year
Personal profile
Personal profile
Dr. Han received her B.S. in Bioscience from Soochow University (2009), M.S. in Bioengineering from Shandong University (2012), and Ph.D. in Chemistry from University of Wisconsin-Milwaukee in the United States (2017). After finishing her Ph.D., she continued her academic career as a postdoctoral research associate at Boston University (2018-2019) and worked as an Assistant Professor at Minnesota State University, Mankato (2021-2022). She is now an Assistant Professor at the Department of Biological Sciences in XJTLU. Dr. Han is an X-ray crystallographer who combines structural biology with enzyme kinetics and other biochemical methods to address questions of enzyme catalysis, with a particular focus on inhibitor/drug design. Her current research focuses on the activation mechanism of the atypical aspartate-less response regulators (ALRs) and proteins involved in fructose metabolism. Dr. Han’s laboratory is open to students of all levels and collaborators seeking assistance in protein crystallization and enzyme kinetics.
Research interests
Aspartate-less response regulators (ALRs)
Fructose metabolism
Enzyme kinetics
Structure based drug design and screening
Experience
Assistant Professor, Department of Biological Sciences, Xian Jiaotong-Liverpool University, September 2022 to Present
Assistant Professor, Department of Biochemistry, Chemistry, and Geology, Minnesota State University Mankato, 2021-2022
Postdoc, Department of Biology, Boston University, 2018-2019
Teaching
BIO312 Protein Structure and Function
BIO303 Final Year Project
BIO209 Higher Organic Chemistry
CHEM 111 Chemistry of Life Process Part II: Organic and Biochemistry, Minnesota State University Mankato
CHEM 106 Chemistry of Life Process I: General Chemistry, Minnesota State University Mankato
CHEM 104 General Chemistry and Qualitative Analysis, University of Wisconsin-Milwaukee
Awards and honours
May 2017 Sosnovksy Award for Excellence in Graduate Research at University of Wisconsin-Milwaukee
2016-2017 Graduate Student Excellence Fellowship (GSEF) Award at University of Wisconsin-Milwaukee
Sep 2015 The Chairs Prize for my poster titled A Novel PLP-Dependent L-Arginine Hydroxylase in L-Enduracididine Biosynthesis at the 35th Midwest Enzyme Chemistry Conference in Chicago, IL
May 2013 The Student Accessibility Center (SAC) Excellence Award at University of Wisconsin-Milwaukee
2008-2009 Peoples comprehensive scholarship at Soochow University
2007-2008 Peoples comprehensive scholarship at Soochow University
2006-2007 Peoples comprehensive scholarship at Soochow University
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Ph.D., University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA - 2017
M.S., Shandong University, Jinan, Shandong, China - 2012
B.S., Soochow University, Suzhou, Jiangsu, China - 2009
Keywords
- QH301 Biology
- Structural Biology
- Drug design
- Drug screening
Person Types
- Staff
Fingerprint
Projects
- 1 Active
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Structure and Inhibitor Development of the Atypical Virulence Regulator in Pseudomonas aeruginosa
1/01/24 → 31/12/26
Project: Internal Research Project
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Correction to: Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase (Biochemistry (2019) 58: 40 (4136−4147) DOI: 10.1021/acs.biochem.9b00652)
Han, L., Vuksanovic, N., Oehm, S. A., Fenske, T. G., Schwabacher, A. W. & Silvaggi, N. R., 10 Dec 2019, In: Biochemistry. 58, 49, p. 5023 1 p.Research output: Contribution to journal › Comment/debate
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RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization
Glanville, D. G., Han, L., Maule, A. F., Woodacre, A., Thanki, D., Abdullah, I. T., Morrissey, J. A., Clarke, T. B., Yesilkaya, H., Silvaggi, N. R. & Ulijasz, A. T., May 2018, In: PLoS Pathogens. 14, 5, e1007052.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase
Han, L., Vuksanovic, N., Oehm, S. A., Fenske, T. G., Schwabacher, A. W. & Silvaggi, N. R., 12 Jun 2018, In: Biochemistry. 57, 23, p. 3252-3264 13 p.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
Swit-4259, an acetoacetate decarboxylase-like enzyme from Sphingomonas wittichii RW1
Mydy, L. S., Mashhadi, Z., Knight, T. W., Fenske, T., Hagemann, T., Hoppe, R. W., Han, L., Miller, T. R., Schwabacher, A. W. & Silvaggi, N. R., Dec 2017, In: Acta Crystallographica Section F: Structural Biology Communications. 73, 12, p. 672-681 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Heterologous expression of carcinoembryonic antigen in Lactococcus lactis via LcsB-mediated surface displaying system for oral vaccine development
Zhang, X., Hu, S., Du, X., Li, T., Han, L. & Kong, J., 1 Dec 2016, In: Journal of Microbiology, Immunology and Infection. 49, 6, p. 851-858 8 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus)
Activities
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Heterologous Expression of the Atypical Virulence Regulator from Pseudomonas aeruginosa
Lanlan Han (Supervisor)
17 Jun 2024 → 9 Aug 2024Activity: Supervision › Completed SURF Project
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The 8th Chinese Protein Society Symposium
Lanlan Han (Participant)
24 Nov 2023 → 26 Nov 2023Activity: Participating in or organising an event › Participating in an event e.g. a conference, workshop, …
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Chinese Society of Biochemistry and Molecular Biology (External organisation)
Lanlan Han (Member)
20 Nov 2023 → 19 Nov 2024Activity: Membership › Membership of committee
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Expression and Purification of Flavobacterium johnsoniae SprB C-Terminal Domain
Lanlan Han (Participant)
10 Sept 2023 → 31 May 2024Activity: Other
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Heterologous Expression of Pseudomonas aeruginosa AtvR Regulatory Domain in Escherichia coli
Lanlan Han (Participant)
10 Sept 2023 → 31 May 2024Activity: Other