Uncovering the Role of Src Family Kinases in Transcriptional Regulation of Neuroinflammation in Migraine Models

Description

Migraine is the second most disabling disease worldwide with complex pathological processes, of which neuroinflammation plays a critical role in facilitating the aberrant hyperexcitability of the central and trigeminovascular system; In particular, cortical spreading depression (CSD) and trigeminovascular sensitization. Src family kinases (SFKs), non-receptor tyrosine kinases, are essential for CSD propagation and sustained trigeminal ganglion (TG) sensitization via promoting the induction of gene expression of neuroinflammatory factors, yet the underlying mechanism is unclear. In this talk, I will introduce our recent findings on the mechanistic role of SFKs in the transcriptional regulation of neuroinflammation in migraine models. Our data revealed for the first time that nuclear SFKs contribute to the transcriptional regulation of key neuroinflammation factors via specific histone modification in complementary ex vivo and in vivo migraine models. These data provide novel insight into the molecular mechanisms underlying the sustained central and trigeminal gangion sensitization in migraine.

Period	2 Dec 2024
Held at	School of Science