ZIKV viral proteins and their roles in virus-host interactions

Moujian Guo, Lixia Hui, Yiwen Nie, Boris Tefsen, Ying Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


The re-emergence of Zika virus (ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKV in the process of ZIKV infection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.

Original languageEnglish
Pages (from-to)709-719
Number of pages11
JournalScience China Life Sciences
Issue number5
Publication statusPublished - May 2021


  • ZIKV
  • host-virus interactions
  • immune response
  • pathogenicity
  • viral protein


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