Zebrafish neurobehavioral phenomics for aquatic neuropharmacology and toxicology research

the International Zebrafish Neuroscience Research Consortium ZNRC

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)

Abstract

Zebrafish (Danio rerio) are rapidly emerging as an important model organism for aquatic neuropharmacology and toxicology research. The behavioral/phenotypic complexity of zebrafish allows for thorough dissection of complex human brain disorders and drug-evoked pathological states. As numerous zebrafish models become available with a wide spectrum of behavioral, genetic, and environmental methods to test novel drugs, here we discuss recent zebrafish phenomics methods to facilitate drug discovery, particularly in the field of biological psychiatry. Additionally, behavioral, neurological, and endocrine endpoints are becoming increasingly well-characterized in zebrafish, making them an inexpensive, robust and effective model for toxicology research and pharmacological screening. We also discuss zebrafish behavioral phenotypes, experimental considerations, pharmacological candidates and relevance of zebrafish neurophenomics to other 'omics' (e.g., genomic, proteomic) approaches. Finally, we critically evaluate the limitations of utilizing this model organism, and outline future strategies of research in the field of zebrafish phenomics.

Original languageEnglish
Pages (from-to)297-309
Number of pages13
JournalAquatic Toxicology
Volume170
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Keywords

  • Aquatic model
  • Behavior
  • Ecotoxicology
  • Neurophenomics
  • Neuropsychopharmacology
  • Zebrafish

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