Zebrafish models relevant to studying central opioid and endocannabinoid systems

Konstantin A. Demin; Darya A. Meshalkina; Elana V. Kysil; Kristina A. Antonova; Andrey D. Volgin; Oleg A. Yakovlev; Polina A. Alekseeva; Maria M. Firuleva; Anton M. Lakstygal; Murilo S. de Abreu; Leonardo J.G. Barcellos; Wandong Bao; Ashton J. Friend; Tamara G. Amstislavskaya; Denis B. Rosemberg; Pavel E. Musienko; Cai Song; Allan V. Kalueff

doi:10.1016/j.pnpbp.2018.03.024

Zebrafish models relevant to studying central opioid and endocannabinoid systems

Konstantin A. Demin, Darya A. Meshalkina, Elana V. Kysil, Kristina A. Antonova, Andrey D. Volgin, Oleg A. Yakovlev, Polina A. Alekseeva, Maria M. Firuleva, Anton M. Lakstygal, Murilo S. de Abreu, Leonardo J.G. Barcellos, Wandong Bao, Ashton J. Friend, Tamara G. Amstislavskaya, Denis B. Rosemberg, Pavel E. Musienko, Cai Song, Allan V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

51 Citations (Scopus)

Abstract

The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms.

Original language	English
Pages (from-to)	301-312
Number of pages	12
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	86
DOIs	https://doi.org/10.1016/j.pnpbp.2018.03.024
Publication status	Published - 30 Aug 2018
Externally published	Yes

Keywords

Endocannabinoid system
High-throughput screening
Opioid system
Zebrafish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pnpbp.2018.03.024

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Demin, K. A., Meshalkina, D. A., Kysil, E. V., Antonova, K. A., Volgin, A. D., Yakovlev, O. A., Alekseeva, P. A., Firuleva, M. M., Lakstygal, A. M., de Abreu, M. S., Barcellos, L. J. G., Bao, W., Friend, A. J., Amstislavskaya, T. G., Rosemberg, D. B., Musienko, P. E., Song, C., & Kalueff, A. V. (2018). Zebrafish models relevant to studying central opioid and endocannabinoid systems. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 86, 301-312. https://doi.org/10.1016/j.pnpbp.2018.03.024

@article{1de83ca6228e4ca6ad42fc6fa8ab09e6,

title = "Zebrafish models relevant to studying central opioid and endocannabinoid systems",

abstract = "The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms.",

keywords = "Endocannabinoid system, High-throughput screening, Opioid system, Zebrafish",

author = "Demin, {Konstantin A.} and Meshalkina, {Darya A.} and Kysil, {Elana V.} and Antonova, {Kristina A.} and Volgin, {Andrey D.} and Yakovlev, {Oleg A.} and Alekseeva, {Polina A.} and Firuleva, {Maria M.} and Lakstygal, {Anton M.} and {de Abreu}, {Murilo S.} and Barcellos, {Leonardo J.G.} and Wandong Bao and Friend, {Ashton J.} and Amstislavskaya, {Tamara G.} and Rosemberg, {Denis B.} and Musienko, {Pavel E.} and Cai Song and Kalueff, {Allan V.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = aug,

day = "30",

doi = "10.1016/j.pnpbp.2018.03.024",

language = "English",

volume = "86",

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journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

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Demin, KA, Meshalkina, DA, Kysil, EV, Antonova, KA, Volgin, AD, Yakovlev, OA, Alekseeva, PA, Firuleva, MM, Lakstygal, AM, de Abreu, MS, Barcellos, LJG, Bao, W, Friend, AJ, Amstislavskaya, TG, Rosemberg, DB, Musienko, PE, Song, C & Kalueff, AV 2018, 'Zebrafish models relevant to studying central opioid and endocannabinoid systems', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 86, pp. 301-312. https://doi.org/10.1016/j.pnpbp.2018.03.024

TY - JOUR

T1 - Zebrafish models relevant to studying central opioid and endocannabinoid systems

AU - Demin, Konstantin A.

AU - Meshalkina, Darya A.

AU - Kysil, Elana V.

AU - Antonova, Kristina A.

AU - Volgin, Andrey D.

AU - Yakovlev, Oleg A.

AU - Alekseeva, Polina A.

AU - Firuleva, Maria M.

AU - Lakstygal, Anton M.

AU - de Abreu, Murilo S.

AU - Barcellos, Leonardo J.G.

AU - Bao, Wandong

AU - Friend, Ashton J.

AU - Amstislavskaya, Tamara G.

AU - Rosemberg, Denis B.

AU - Musienko, Pavel E.

AU - Song, Cai

AU - Kalueff, Allan V.

PY - 2018/8/30

Y1 - 2018/8/30

N2 - The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms.

AB - The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms.

KW - Endocannabinoid system

KW - High-throughput screening

KW - Opioid system

KW - Zebrafish

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U2 - 10.1016/j.pnpbp.2018.03.024

DO - 10.1016/j.pnpbp.2018.03.024

M3 - Review article

C2 - 29604314

AN - SCOPUS:85047070946

SN - 0278-5846

VL - 86

SP - 301

EP - 312

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

ER -

Zebrafish models relevant to studying central opioid and endocannabinoid systems

Abstract

Keywords

UN SDGs

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