Epigenetic regulation has become a key focus of neuroscience and biopsychiatry, implicating DNA methylation, histone modification and other epigenetic mechanisms in various CNS disorders. Animal (experimental) models are a useful tool for epigenetic studies. Although most such research has been performed in rodents, the zebrafish (Danio rerio) is rapidly emerging as a new promising model organism in neuroscience. These fish are particularly suitable for genetic and epigenetic studies due to their fully sequenced genome, easiness of genetic analyses and high physiological and genetic homology with humans. Here, we discuss mounting evidence of epigenetic regulation of CNS functions in zebrafish, and outline future directions of translational research in this field.

Original languageEnglish
Pages (from-to)344-351
Number of pages8
JournalBrain Research Bulletin
Publication statusPublished - Sept 2018
Externally publishedYes


  • Behavior
  • DNA methylation
  • Epigenetics
  • Histone modification
  • Translational psychiatry
  • Zebrafish


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