TY - JOUR
T1 - X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors
AU - Shrestha, Samana
AU - Wu, Jing
AU - Sah, Bindeshwar
AU - Vanasse, Adam
AU - Cooper, Leon N.
AU - Ma, Lun
AU - Li, Gen
AU - Zheng, Huibin
AU - Chen, Wei
AU - Antosh, Michael P.
N1 - Publisher Copyright:
© 2019 National Academy of Sciences. All rights reserved.
PY - 2019/8/20
Y1 - 2019/8/20
N2 - Photodynamic therapy (PDT), a treatment that uses a photosensitizer, molecular oxygen, and light to kill target cells, is a promising cancer treatment method. However, a limitation of PDT is its dependence on light that is not highly penetrating, precluding the treatment of tumors located deep in the body. Copper-cysteamine nanoparticles are a new type of photosensitizer that can generate cytotoxic singlet oxygen molecules upon activation by X-rays. In this paper, we report on the use of copper-cysteamine nanoparticles, designed to be targeted to tumors, for X-ray–induced PDT. In an in vivo study, results show a statistically significant reduction in tumor size under X-ray activation of pH-low insertion peptide–conjugated, copper-cysteamine nanoparticles in mouse tumors. This work confirms the effectiveness of copper-cysteamine nanoparticles as a photosensitizer when activated by radiation and suggests that these Cu-Cy nanoparticles may be good candidates for PDT in deeply seated tumors when combined with X-rays and conjugated to a tumor-targeting molecule.
AB - Photodynamic therapy (PDT), a treatment that uses a photosensitizer, molecular oxygen, and light to kill target cells, is a promising cancer treatment method. However, a limitation of PDT is its dependence on light that is not highly penetrating, precluding the treatment of tumors located deep in the body. Copper-cysteamine nanoparticles are a new type of photosensitizer that can generate cytotoxic singlet oxygen molecules upon activation by X-rays. In this paper, we report on the use of copper-cysteamine nanoparticles, designed to be targeted to tumors, for X-ray–induced PDT. In an in vivo study, results show a statistically significant reduction in tumor size under X-ray activation of pH-low insertion peptide–conjugated, copper-cysteamine nanoparticles in mouse tumors. This work confirms the effectiveness of copper-cysteamine nanoparticles as a photosensitizer when activated by radiation and suggests that these Cu-Cy nanoparticles may be good candidates for PDT in deeply seated tumors when combined with X-rays and conjugated to a tumor-targeting molecule.
KW - Cancer
KW - Copper-cysteamine
KW - Nanoparticles
KW - Photosensitization
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85071238026&partnerID=8YFLogxK
U2 - 10.1073/pnas.1900502116
DO - 10.1073/pnas.1900502116
M3 - Article
C2 - 31371494
AN - SCOPUS:85071238026
SN - 0027-8424
VL - 116
SP - 16823
EP - 16828
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 34
ER -