Universal antibacterial surfaces fabricated from quaternary ammonium salt-based pnipam microgels

Ziqing Zhao, Xiaoliang Ma, Rui Chen*, Hui Xue, Jiehua Lei, Hui Du, Zexin Zhang, Hong Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


Because of the excellent film-forming ability of poly(N-isopropylacrylamide) (PNIPAM) microgel and high-efficient bactericidal property of quaternary ammonium salt (QAS), QAS-based PNIPAM (QAS-PNIPAM) microgels are synthesized and employed to modify the surface of a range of commonly used materials including metal, plastic, and elastomer. Bacterial culture is carried out on such QAS-PNIPAM microgel-modified surfaces to examine the viability of the attached bacteria. It is found that the bactericidal efficiency is nearly 100% on the modified surfaces of all the studied materials. We attribute the high-efficient bactericidal performance of QAS-PNIPAM microgel film to the QAS component rather than the topography of the microgel film itself. In addition, the microgel film is robust and shows great integrity even after culture of the bacteria and repeated rinses, and the cell experiment demonstrates that this microgel film is cyto-compatible. Therefore, such a simple, versatile method of preparing antibacterial films paves the way for future bactericidal applications.

Original languageEnglish
Pages (from-to)19268-19276
Number of pages9
JournalACS Applied Materials and Interfaces
Issue number17
Publication statusPublished - 29 Apr 2020
Externally publishedYes


  • Antibacteria
  • Particle film
  • Pnipam microgels
  • Quaternary ammonium salt
  • Universality


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