TY - JOUR
T1 - Understanding the genetic architectonics of complex CNS traits
T2 - Lost by the association, but found in the interaction?
AU - Stewart, Adam Michael
AU - Nguyen, Michael
AU - Song, Cai
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© British Association for Psychopharmacology.
PY - 2015/8/23
Y1 - 2015/8/23
N2 - Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.
AB - Recent evidence supports the value of endophenotypes and genome-wide association studies in psychiatric genetics, and their importance for dissecting the neural pathways and molecular mechanisms of complex neuropsychiatric disorders. Continuing this important discussion, here we outline three new mechanisms by which novel classes of genes may facilitate CNS pathogenesis without directly worsening its individual 'established' endophenotypes. These putative genetic mechanisms can apply to other human disorders in general, and may also be used for designing novel effective CNS drug treatments.
KW - Brain disorder
KW - Endophenotype
KW - Neuropsychiatric domain
KW - Pathogenetic interplay/overlap
KW - Spectrum of brain disorders
UR - http://www.scopus.com/inward/record.url?scp=84937893857&partnerID=8YFLogxK
U2 - 10.1177/0269881115593904
DO - 10.1177/0269881115593904
M3 - Article
C2 - 26156859
AN - SCOPUS:84937893857
SN - 0269-8811
VL - 29
SP - 872
EP - 877
JO - Journal of Psychopharmacology
JF - Journal of Psychopharmacology
IS - 8
ER -
