Hallucinogenic drugs potently alter human behavior and have a millennia-long history of use for medicinal and religious purposes. Interest is rapidly growing in their potential as CNS modulators and therapeutic agents for brain conditions. Antimuscarinic cholinergic drugs, such as atropine and scopolamine, induce characteristic hyperactivity and dream-like hallucinations and form a separate group of hallucinogens known as "deliriants". Although atropine and scopolamine are relatively well-studied drugs in cholinergic physiology, deliriants represent the least-studied class of hallucinogens in terms of their behavioral and neurological phenotypes. As such, novel approaches and new model organisms are needed to investigate the CNS effects of these compounds. Here, we comprehensively evaluate the preclinical effects of deliriant hallucinogens in various animal models, their mechanisms of action, and potential interplay with other signaling pathways. We also parallel experimental and clinical findings on deliriant agents and outline future directions of translational research in this field.

Original languageEnglish
Pages (from-to)143-154
Number of pages12
JournalACS Chemical Neuroscience
Issue number1
Publication statusPublished - 16 Jan 2019
Externally publishedYes


  • antimuscarinic agents
  • deliriants
  • Hallucinogens
  • rodents
  • zebrafish


Dive into the research topics of 'Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models'. Together they form a unique fingerprint.

Cite this