Twisted amide analogues of Tröger's base

Josep Artacho, Erhad Ascic, Toni Rantanen, Josefine Karlsson, Carl Johan Wallentin, Ruiyao Wang, Ola F. Wendt, Michael Harmata, Victor Snieckus, Kenneth Wärnmark*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Let's do the twist: The first twisted bis-amide (see figure) is obtained by the benzylic oxidation of Tröger's base (TB). Kinetic studies of its acidic hydrolysis reveal that the hydrolysis is to a large extent funneled through doubly protonated species.

Original languageEnglish
Pages (from-to)1038-1042
Number of pages5
JournalChemistry - A European Journal
Issue number4
Publication statusPublished - 23 Jan 2012
Externally publishedYes


  • Tröger's base
  • X-ray structures
  • hydrolysis
  • oxidation
  • twisted amides

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